Structural and Functional Properties of NAD Kinase, a Key Enzyme in NADP Biosynthesis

Title: Structural and Functional Properties of NAD Kinase, a Key Enzyme in NADP Biosynthesis

Volume: 6 Issue: 7

Author(s): Giulio Magni, Giuseppe Orsomando and Nadia Raffaelli

Affiliation:

Keywords: NADP biosynthesis, pyridine dinucleotides, recombinant protein, antimicrobial agents, kinetic analysis

Abstract: NAD kinase is an essential enzyme, which plays a key role in cellular energy and signal transduction systems. Inthis report, the recent studies on the features of bacterial and human NAD kinases are summarized. They include detailedkinetic and structural analyses and highlight important differences, which could be exploited for the design of novelselective antimicrobial drugs.

Cite this article as:

Magni Giulio, Orsomando Giuseppe and Raffaelli Nadia, Structural and Functional Properties of NAD Kinase, a Key Enzyme in NADP Biosynthesis, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698688