Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties

Title:Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties

Volume: 12 Issue: 14

Author(s): M.S. Pino-Gonzalez, N. Ona and A. Romero-Carrasco

Affiliation:

Keywords: Calystegine, Polydroxylated Nortropane, Polydroxylated Alkaloid, Glycosidase Inhibitor, dihydroxynortropanes, hemiaminal, biogenetic, pyrrolidines

Abstract: The revision of the structures and properties of Calystegines shows that they can be regarded as carbohydrate mimics, with related biological activities and peculiar characteristics. Not only they can be isolated from food plants, but they can be obtained from a variety of monosaccharide derivatives and of non-carbohydrate products. Although several synthetic calystegine analogs have been reported as glycosidase inhibitors, new, more potent and effective inhibitors are required.

Cite this article as:

Pino-Gonzalez M.S., Ona N. and Romero-Carrasco A., Advances in the Synthesis of Calystegines and Related Products and their Biochemical Properties, Mini-Reviews in Medicinal Chemistry 2012; 12 (14) . https://dx.doi.org/10.2174/138955712803832708