Fused 1,4-Dihydropyridines as Potential Calcium Modulatory Compounds

Title: Fused 1,4-Dihydropyridines as Potential Calcium Modulatory Compounds

Volume: 6 Issue: 7

Author(s): Cihat Safak and Rahime Simsek

Affiliation:

Keywords: 1,4-Dihydropyridine, hexahydroquinoline, calcium modulatory activity, synthesis, biotransformation, structure-activity relationships

Abstract: 1,4-Dihydropyridine (1,4-DHP) derivatives nifedipine of which the prototype, are the most popular drugs having calcium antagonistic activity. Fused 1,4-dihydropyridines (DHPs) have also exhibit calcium modulatory activities. In this article, weemphasizecalcium channels and fused 1,4-DHP derivatives affecting calcium channels. In addition, the basic considerations of synthesis, metabolism, structure-activity relationships and the latest developments on fused 1,4-DHP derivatives will be reviewed. This review also has extended examples of fused 1,4-DHP derivatives having cited activities synthesized by our group.

Cite this article as:

Safak Cihat and Simsek Rahime, Fused 1,4-Dihydropyridines as Potential Calcium Modulatory Compounds, Mini-Reviews in Medicinal Chemistry 2006; 6 (7) . https://dx.doi.org/10.2174/138955706777698606