Generic placeholder image

Current Neuropharmacology

Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species

Author(s): Peter Kovacic and Ratnasamy Somanathan

Volume 10, Issue 4, 2012

Page: [289 - 302] Pages: 14

DOI: 10.2174/1570159X11209040289

Price: $65

Abstract

Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.

Keywords: Redox, neurodegenerative diseases, reactive oxygen species, oxidative stress


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy