Abstract
Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.
Keywords: Redox, neurodegenerative diseases, reactive oxygen species, oxidative stress
Current Neuropharmacology
Title:Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species
Volume: 10 Issue: 4
Author(s): Peter Kovacic and Ratnasamy Somanathan
Affiliation:
Keywords: Redox, neurodegenerative diseases, reactive oxygen species, oxidative stress
Abstract: Much attention has been devoted to neurodegenerative diseases involving redox processes. This review comprises an update involving redox processes reported in the considerable literature in recent years. The mechanism involves reactive oxygen species and oxidative stress, usually in the brain. There are many examples including Parkinson’s, Huntington’s, Alzheimer’s, prions, Down’s syndrome, ataxia, multiple sclerosis, Creutzfeldt-Jacob disease, amyotrophic lateral sclerosis, schizophrenia, and Tardive Dyskinesia. Evidence indicates a protective role for antioxidants, which may have clinical implications. A multifaceted approach to mode of action appears reasonable.
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Cite this article as:
Kovacic Peter and Somanathan Ratnasamy, Redox Processes in Neurodegenerative Disease Involving Reactive Oxygen Species, Current Neuropharmacology 2012; 10 (4) . https://dx.doi.org/10.2174/1570159X11209040289
DOI https://dx.doi.org/10.2174/1570159X11209040289 |
Print ISSN 1570-159X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6190 |
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