Abstract
The synthesis of α,β-dehydro-α-aminophosphonic and α,β-dehydro-α-aminophosphinic acid derivatives is discussed. The most important synthetic pathways to the above-mentioned compounds have been divided into four groups depending on the type of bond formed as the last one. The configuration at the C=C double bond can be established based on the specific coupling constants 3JHP and 3JCP for the appropriate Z- and E-stereoisomers. The application of α,β-dehydro-α-aminophosphonates and α,β-dehydro-α- aminophosphinates, particularly in the enantioselective catalytic hydrogenation, is also discussed.
Keywords: α -aminophosphinic acids, α -aminophosphonic acids, asymmetric catalytic hydrogenation, α , β -dehydro-α-aminophosphinates, α, β-dehydro-α-aminophosphonates, Michaelis-Arbuzov reaction, Wadsworth-Emmons reaction.
Current Organic Synthesis
Title:Synthesis, Structure and Application of α, β Dehydro-α-aminophosphonic and α,β-Dehydro-α-aminophosphinic Acid Derivatives
Volume: 10 Issue: 3
Author(s): Anna Kuznik, Roman Mazurkiewicz and Nikodem Kuznik
Affiliation:
Keywords: α -aminophosphinic acids, α -aminophosphonic acids, asymmetric catalytic hydrogenation, α , β -dehydro-α-aminophosphinates, α, β-dehydro-α-aminophosphonates, Michaelis-Arbuzov reaction, Wadsworth-Emmons reaction.
Abstract: The synthesis of α,β-dehydro-α-aminophosphonic and α,β-dehydro-α-aminophosphinic acid derivatives is discussed. The most important synthetic pathways to the above-mentioned compounds have been divided into four groups depending on the type of bond formed as the last one. The configuration at the C=C double bond can be established based on the specific coupling constants 3JHP and 3JCP for the appropriate Z- and E-stereoisomers. The application of α,β-dehydro-α-aminophosphonates and α,β-dehydro-α- aminophosphinates, particularly in the enantioselective catalytic hydrogenation, is also discussed.
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Cite this article as:
Kuznik Anna, Mazurkiewicz Roman and Kuznik Nikodem, Synthesis, Structure and Application of α, β Dehydro-α-aminophosphonic and α,β-Dehydro-α-aminophosphinic Acid Derivatives, Current Organic Synthesis 2013; 10 (3) . https://dx.doi.org/10.2174/1570179411310030006
DOI https://dx.doi.org/10.2174/1570179411310030006 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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