Abstract
Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.
Keywords: Dual functional probes, Fluorescent probe, Misfolding proteins, Neurodegenerative disease, In vivo imaging, Fluorescent imaging, Near infrared imaging, Alzheimer’s disease, Neurodegenerative diseases
Current Organic Chemistry
Title:Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins
Volume: 17 Issue: 6
Author(s): Xueli Zhang and Chongzhao Ran
Affiliation:
Keywords: Dual functional probes, Fluorescent probe, Misfolding proteins, Neurodegenerative disease, In vivo imaging, Fluorescent imaging, Near infrared imaging, Alzheimer’s disease, Neurodegenerative diseases
Abstract: Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.
Export Options
About this article
Cite this article as:
Zhang Xueli and Ran Chongzhao, Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins, Current Organic Chemistry 2013; 17 (6) . https://dx.doi.org/10.2174/1385272811317060004
DOI https://dx.doi.org/10.2174/1385272811317060004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Ubiquitin and ubiquitin-like proteins in cardiac disease and protection
Current Drug Targets Weight Loss in Older Persons: New Therapeutic Approaches
Current Pharmaceutical Design Key Role of Mitochondria in Alzheimer’s Disease Synaptic Dysfunction
Current Pharmaceutical Design Recent Advances in the Medicinal Chemistry of Sodium Channel Blockers and their Therapeutic Potential
Current Topics in Medicinal Chemistry Musculoskeletal Adverse Drug Reactions: A Review of Literature and Data from ADR Spontaneous Reporting Databases
Current Drug Safety Immune Aging and Autoimmune Diseases in Children
Current Immunology Reviews (Discontinued) Is the Vagina an Adequate Route for the Administration of Hormonal Contraceptives?
Current Drug Metabolism Multiple Sclerosis: Current and Future Treatment Options
Endocrine, Metabolic & Immune Disorders - Drug Targets A proteomics based approach for the identification of gastric cancer related markers
Current Pharmaceutical Design Muscle Metabolism and Exercise Capacity in Cachexia
Current Pharmaceutical Design Patent Selections:
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Therapeutic Potential of Hepatocyte Growth Factor for Treating Neurological Diseases
Current Drug Therapy Remyelination in Multiple Sclerosis: The Therapeutic Potential of Neural and Mesenchymal Stem/Progenitor Cells
Current Signal Transduction Therapy Clinical Molecular Imaging with PET Agents Other than 18F-FDG
Current Pharmaceutical Biotechnology Pompe Disease and Autophagy: Partners in Crime, or Cause and Consequence?
Current Medicinal Chemistry SDH Genes: From Glomic Tumours to Pheochromocytomas
Current Hypertension Reviews The Traces of Sound: Taking the Road to Skin
Current Rheumatology Reviews From Genomic Imprinting to Developmental Physiology: Identifying Stepping Stones
Current Pharmacogenomics Infectious Agents and Neurodegenerative Diseases: Exploring the Links
Current Topics in Medicinal Chemistry Female Sexual Dysfunction: Therapeutic Options and Experimental Challenges
Cardiovascular & Hematological Agents in Medicinal Chemistry