Abstract
Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.
Keywords: Dual functional probes, Fluorescent probe, Misfolding proteins, Neurodegenerative disease, In vivo imaging, Fluorescent imaging, Near infrared imaging, Alzheimer’s disease, Neurodegenerative diseases
Current Organic Chemistry
Title:Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins
Volume: 17 Issue: 6
Author(s): Xueli Zhang and Chongzhao Ran
Affiliation:
Keywords: Dual functional probes, Fluorescent probe, Misfolding proteins, Neurodegenerative disease, In vivo imaging, Fluorescent imaging, Near infrared imaging, Alzheimer’s disease, Neurodegenerative diseases
Abstract: Misfolding of a protein is a destructive process for variety of diseases that include neurodegenerative diseases such as Alzheimer’s disease, Parkinson disease, Huntington disease, mad cow disease, amyotrophic lateral sclerosis (ALS), and frontal temporal dementia (FTD), and other non-CNS diseases such as diabetes, cystic fibrosis, and lysosomal storage diseases. Formation of various misfunctional large assembles of the misfolded protein is the primary consequence. To detect the formation of the aggregated species is very important for not only basic mechanism research but also very crucial for diagnosis of the diseases. In this review, we updated references related to the new development of the dual functional fluorescent small molecule probes for detecting the aggregated proteins in vitro and in vivo.
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Cite this article as:
Zhang Xueli and Ran Chongzhao, Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins, Current Organic Chemistry 2013; 17 (6) . https://dx.doi.org/10.2174/1385272811317060004
DOI https://dx.doi.org/10.2174/1385272811317060004 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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