Abstract
Nowadays, dietary guidelines acknowledge the therapeutic role of omega-3 polyunsaturated fatty acids, as the most important class of fatty acids, against different human diseases. During the last two decades, the average level of consumption of omega-3 polyunsaturated fatty acids has increased from 0.1 to 0.2 g per day. Omega-3 polyunsaturated fatty acids are a group of long-chain polyunsaturated fatty acids which are identified in different foods such as fatty fish, shellfish, and vegetable oils. A growing body of epidemiological and experimental evidence supports the anticancer effects of omega-3 polyunsaturated fatty acids, which led to the identification of their molecular targets in several cancer models. The present review focuses on the basic evidence supporting the potential applications of omega-3 polyunsaturated fatty acids in cancer therapy.
Keywords: Anticancer, fish oil, molecular targets, omega-3 polyunsaturated fatty acids.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy
Volume: 15 Issue: 7
Author(s): K. Pandima Devi, T. Rajavel, G. L. Russo, M. Daglia, S. F. Nabavi and S. M. Nabavi
Affiliation:
Keywords: Anticancer, fish oil, molecular targets, omega-3 polyunsaturated fatty acids.
Abstract: Nowadays, dietary guidelines acknowledge the therapeutic role of omega-3 polyunsaturated fatty acids, as the most important class of fatty acids, against different human diseases. During the last two decades, the average level of consumption of omega-3 polyunsaturated fatty acids has increased from 0.1 to 0.2 g per day. Omega-3 polyunsaturated fatty acids are a group of long-chain polyunsaturated fatty acids which are identified in different foods such as fatty fish, shellfish, and vegetable oils. A growing body of epidemiological and experimental evidence supports the anticancer effects of omega-3 polyunsaturated fatty acids, which led to the identification of their molecular targets in several cancer models. The present review focuses on the basic evidence supporting the potential applications of omega-3 polyunsaturated fatty acids in cancer therapy.
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Devi Pandima K., Rajavel T., Russo L. G., Daglia M., Nabavi F. S. and Nabavi M. S., Molecular Targets of Omega-3 Fatty Acids for Cancer Therapy, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (7) . https://dx.doi.org/10.2174/1871520615666150424124606
DOI https://dx.doi.org/10.2174/1871520615666150424124606 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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