Abstract
Drug development continues to be time consuming, expensive and less efficient, while drug therapy is often administered at suboptimal levels. This is particularly true with anti-infectives for HIV and tuberculosis. The application of pharmacometric principles and models to drug development and pharmacotherapy will improve the drug approval process and selection of optimal dosage regimens or therapeutic combinations. In this review we mainly focus on the utilities of pharmacometrics in the dose selections of anti-retroviral and anti-tubercular drugs. We will examine how pharmacometrics have been useful in the area of dose selections, preclinical to clinical scaling, subpopulation selections, combination therapies, adherence assessments, and resistance prevention dosing strategies.
Keywords: Pharmacokinetics, pharmacodynamics, pharmacometrics, anti-retroviral, anti-tubercular, modeling, simulation, Drug development, drug therapy, anti-infectives, tuberculosis, pharmacotherapy, therapeutic combinations, dose selections, adherence assessments
Infectious Disorders - Drug Targets
Title: Pharmacometrics in Dose Finding or Dose Optimization of Anti-Retroviral and Anti-Tubercular Drugs
Volume: 11 Issue: 2
Author(s): Sreedharan Nair Sabarinath, Benjamin Wu, Charles Peloquin and Hartmut Derendorf
Affiliation:
Keywords: Pharmacokinetics, pharmacodynamics, pharmacometrics, anti-retroviral, anti-tubercular, modeling, simulation, Drug development, drug therapy, anti-infectives, tuberculosis, pharmacotherapy, therapeutic combinations, dose selections, adherence assessments
Abstract: Drug development continues to be time consuming, expensive and less efficient, while drug therapy is often administered at suboptimal levels. This is particularly true with anti-infectives for HIV and tuberculosis. The application of pharmacometric principles and models to drug development and pharmacotherapy will improve the drug approval process and selection of optimal dosage regimens or therapeutic combinations. In this review we mainly focus on the utilities of pharmacometrics in the dose selections of anti-retroviral and anti-tubercular drugs. We will examine how pharmacometrics have been useful in the area of dose selections, preclinical to clinical scaling, subpopulation selections, combination therapies, adherence assessments, and resistance prevention dosing strategies.
Export Options
About this article
Cite this article as:
Nair Sabarinath Sreedharan, Wu Benjamin, Peloquin Charles and Derendorf Hartmut, Pharmacometrics in Dose Finding or Dose Optimization of Anti-Retroviral and Anti-Tubercular Drugs, Infectious Disorders - Drug Targets 2011; 11 (2) . https://dx.doi.org/10.2174/187152611795589681
DOI https://dx.doi.org/10.2174/187152611795589681 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Results of a Community-Based Antiretroviral Treatment Program for HIV-1 Infection in Western Uganda
Current HIV Research Bacteriophages as Therapeutic Agents: Alternatives to Antibiotics
Recent Patents on Biotechnology Quickness of HIV and Tuberculosis Diagnostic Procedures in Prison of Tehran, Iran
Infectious Disorders - Drug Targets Synthesis, <i>In silico</i> and <i>In vitro</i> Analysis of Hydrazones as Potential Antituberculosis Agents
Current Computer-Aided Drug Design Toxic Effects of Aflatoxin B1 on Embryonic Development of Zebrafish (Danio rerio): Potential Activity of Piceatannol Encapsulated Chitosan/poly (Lactic Acid) Nanoparticles
Anti-Cancer Agents in Medicinal Chemistry Prediction and Analysis of the Protein-Protein Interaction Networks for Chickens, Cattle, Dogs, Horses and Rabbits
Current Bioinformatics Biologically Active 4-Thiazolidinones: A Review of QSAR Studies and QSAR Modeling of Antitumor Activity
Current Topics in Medicinal Chemistry SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450
Protein & Peptide Letters Bioactive Carbohydrates and Recently Discovered Analogues as Chemotherapeutics
Mini-Reviews in Medicinal Chemistry Editorial
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Targeting Monoamine Oxidases with Multipotent Ligands: An Emerging Strategy in the Search of New Drugs Against Neurodegenerative Diseases
Current Medicinal Chemistry Asthma and High Altitude: Is It Safe to Be and Work?
Current Respiratory Medicine Reviews The Synthetic and Biological Attributes of Pyrazole Derivatives: A Review
Mini-Reviews in Medicinal Chemistry Vitamin D is Related to Markers of Vulnerable Plaque in Acute Myocardial Infarction
Current Vascular Pharmacology Targeting the Human Thioredoxin System by Diverse Strategies to Treat Cancer and Other Pathologies
Recent Patents on DNA & Gene Sequences In-vitro Antioxidant activity of ‘Aswathy Chooranam’- a Siddha Drug
Current Traditional Medicine Editorial [Hot Topic: Carbonic Anhydrases: Again, and Again, and Again (Executive Editor: Claudiu T. Supuran)]
Current Pharmaceutical Design Novel Strategies to Combat the Emerging Drug Resistance in Human Pathogenic Microbes
Current Drug Targets Microwave-assisted Single Step Cinnamic Acid Derivatization and Evaluation for Cytotoxic Potential
Current Pharmaceutical Biotechnology Medicinal Research Progress of Natural Coumarin and its Derivatives
The Natural Products Journal