Effects of Bioactive Peptide on Inflammatory Bowel Disease, Focus on Signal Transduction and Intestinal Microbiota

Title:Effects of Bioactive Peptide on Inflammatory Bowel Disease, Focus on Signal Transduction and Intestinal Microbiota

Volume: 24 Issue: 24

Author(s): Yong Ma, Wenxin Yan, Sujuan Ding, Yanquan Fei, Gang Liu* Jun Fang*

Affiliation:

• College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128,China

• College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, Hunan 410128,China

Keywords: Inflammatory bowel diseases, bioactive peptide, intestinal microbiota, defensins, chronic disease, antibiotics.

Abstract: Inflammatory Bowel Diseases (IBD) are now widely receiving attention. There are many reasons why people get IBD; for example, environment, smoking, family heredity, intestinal microbiota and so on. Antibiotics have not been proven effective and those suffering from IBD have begun to look for other effective drugs to treat the chronic disease. Bioactive peptides are a good candidate among alternative drugs tested so far, and have been seen to control bodily growth, development, immune regulation and metabolism. This paper will review the literature describing the effects of bioactive peptides on intestinal inflammation. Studies conducted using in vivo models and clinical trials provide evidence that bioactive peptides can be effective in mitigating intestinal inflammation.

Cite this article as:

Ma Yong, Yan Wenxin , Ding Sujuan , Fei Yanquan , Liu Gang *, Fang Jun *, Effects of Bioactive Peptide on Inflammatory Bowel Disease, Focus on Signal Transduction and Intestinal Microbiota, Current Pharmaceutical Design 2018; 24 (24) . https://dx.doi.org/10.2174/1381612824666180829103945