Abstract
Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomachand cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer.
Keywords: Gastric cancer, carcinoma, gastric ulcer, gene delivery, stomach
Current Gene Therapy
Title: Gene Therapy for Gastric Diseases
Volume: 8 Issue: 3
Author(s): Shintaro Fumoto, Junya Nishi, Junzo Nakamura and Koyo Nishida
Affiliation:
Keywords: Gastric cancer, carcinoma, gastric ulcer, gene delivery, stomach
Abstract: Gene therapy for gastric cancer and gastric ulcer is a rationalized strategy since various genes correlate with these diseases. Since gene expressions in non-target tissues/cells cause side effects, a selective gene delivery system targeted to the stomach and/or cancer must be developed. The route of vector transfer (direct injection, systemic, intraperitoneal, gastric serosal surface and oral administration) is an important issue which can determine efficacy and safety. Strategies for cancer gene therapy can be categorized as suicide gene therapy, growth inhibition and apoptosis induction, immunotherapy, anti-angiogenesis, and others. Combination of the target gene with other genes and/or strategies such as chemotherapy and virotherapy is promising. Candidates for treatment of gastric ulcer are vascular endothelial growth factor, angiopoietin-1, serum response factor, and cationic host defense peptide cathelicidin. In this review, we discuss stomachand cancer-targeted gene transfer methods and summarize gene therapy trials for gastric cancer and gastric ulcer.
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Cite this article as:
Fumoto Shintaro, Nishi Junya, Nakamura Junzo and Nishida Koyo, Gene Therapy for Gastric Diseases, Current Gene Therapy 2008; 8 (3) . https://dx.doi.org/10.2174/156652308784746431
DOI https://dx.doi.org/10.2174/156652308784746431 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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