Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer

Title:Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer

Volume: 17 Issue: 7

Author(s): Snehal S. Patel*Surender Nakka

Affiliation:

• Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382 481,India

Keywords: Angiogenesis, angiotensin converting enzyme inhibitors, breast cancer, perindopril, tumor progression.

Abstract: Background: Studies have shown that the renin angiotensin system via angiogenesis is involved in tumor development.

Objective: Therefore, objective of the present study was to examine the effect of perindopril on tumor growth and angiogenesis in animal models of breast cancer.

Methods: In the present study, the effect of perindopril on tumor development of mammary gland cancer induced by 7,12-dimethylbenz[a]anthracene, mouse tumor xenograft and corneal micropocket model has been investigated. Anti-angiogenic effect by chick yolk sac membrane assay has also been studied.

Results: In the present study, it has been found that perindopril produced a significant inhibition of tumor growth, in DMBA induced breast cancer. Treatment also produced significant suppression of cancer biomarkers such as lactate dehydrogenase, gamma glutamyl transferase and inflammatory markers such as C-reactive protein, erythrocyte sedimentation rate. Histopathological analysis also showed that perindopril was able to inhibit tumor development by the inhibition of hyperplastic lesions. Perindopril produced significant inhibition of tumor growth, in a mouse xenograft model and caused inhibition of neovascularization in the corneal micropocket model. In chick yolk sac membrane assay, perindopril showed inhibition of vascular growth and reduced blood vessel formation.

Conclusion: Therefore, perindopril is widely used in clinical practice, may represent a neo-adjuvant therapy for treatment of breast cancer.

Cite this article as:

Patel S. Snehal*, Nakka Surender, Protective Effect of Perindopril on Tumor Progression and Angiogenesis in Animal Model of Breast Cancer, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (7) . https://dx.doi.org/10.2174/1871520616666160817143141

DOI https://dx.doi.org/10.2174/1871520616666160817143141	Print ISSN 1871-5206
Publisher Name Bentham Science Publisher	Online ISSN 1875-5992