Abstract
Biofilms are among the most important causes of nosocomial and recurrent infections as biofilms confer antibiotic resistance to pathogenic bacteria and protect them from the host’s immune system. Thus, it is imperative to investigate effective therapeutic agents to counteract biofilms. As an important signaling molecule, Nitric Oxide (NO) plays a crucial role in various biological and pathological processes. NO could disperse biofilm and restore the drug sensitivity by reducing intracellular cyclic-diguanosine monophosphate (c-di-GMP) levels. This review highlights recent advances on antibacterial and antibiofilm effects of NO when NO was co-administered with other antimicrobial agents. A significant improvement in drug permeability and biofilm cell targeting and reduced cytotoxicity could be attained with this strategy. In this review, we briefly lay out challenges and propose future directions in this appealing avenue of research on NO-based therapy for biofilm eradication.
Keywords: Nitric oxide (NO), Biofilm eradication, Antibiotic resistance, Bis-(3′-5′)-cyclic-diguanosine monophosphate (c-di- GMP), Antibacterial therapy, Pathogenic infection.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:The Insights and Perspectives of Nitric Oxide-mediated Biofilm Eradication
Volume: 21 Issue: 24
Author(s): Mingke Yuan, Tao Sun, Jianbing Wu, Yue Fei, Yueqi Yang, Yong Ling, Yihua Zhang and Zhangjian Huang*
Affiliation:
- State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, China Pharmaceutical University, Nanjing210009,China
Keywords: Nitric oxide (NO), Biofilm eradication, Antibiotic resistance, Bis-(3′-5′)-cyclic-diguanosine monophosphate (c-di- GMP), Antibacterial therapy, Pathogenic infection.
Abstract: Biofilms are among the most important causes of nosocomial and recurrent infections as biofilms confer antibiotic resistance to pathogenic bacteria and protect them from the host’s immune system. Thus, it is imperative to investigate effective therapeutic agents to counteract biofilms. As an important signaling molecule, Nitric Oxide (NO) plays a crucial role in various biological and pathological processes. NO could disperse biofilm and restore the drug sensitivity by reducing intracellular cyclic-diguanosine monophosphate (c-di-GMP) levels. This review highlights recent advances on antibacterial and antibiofilm effects of NO when NO was co-administered with other antimicrobial agents. A significant improvement in drug permeability and biofilm cell targeting and reduced cytotoxicity could be attained with this strategy. In this review, we briefly lay out challenges and propose future directions in this appealing avenue of research on NO-based therapy for biofilm eradication.
Export Options
About this article
Cite this article as:
Yuan Mingke , Sun Tao , Wu Jianbing , Fei Yue , Yang Yueqi , Ling Yong , Zhang Yihua and Huang Zhangjian *, The Insights and Perspectives of Nitric Oxide-mediated Biofilm Eradication, Current Topics in Medicinal Chemistry 2021; 21 (24) . https://dx.doi.org/10.2174/1568026621666210701113043
DOI https://dx.doi.org/10.2174/1568026621666210701113043 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
miRNA: Small Molecules as Potential Novel Biomarkers in Cancer
Current Medicinal Chemistry Clinical Research in India - Current Scenario and the Need of the Hour
Applied Clinical Research, Clinical Trials and Regulatory Affairs Protective Mechanisms of Helminths Against Reactive Oxygen Species are Highly Promising Drug Targets
Current Medicinal Chemistry A Summary of Electrospun Nanofibers as Drug Delivery System: Drugs Loaded and Biopolymers Used as Matrices
Current Drug Delivery Benefits of Caloric Restriction on Brain Aging and Related Pathological States: Understanding Mechanisms to Devise Novel Therapies
Current Medicinal Chemistry Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions
Current Neuropharmacology Targeting the Cancer Biomarker CD47: A Review on the Diverse Mechanisms of the CD47 Pathway in Cancer Treatment
Anti-Cancer Agents in Medicinal Chemistry Therapeutic Applications of Capsaicin in Upper Airways
Current Drug Targets Peripheral Biomarkers to Assess Suicide Risk
Current Psychiatry Reviews B Cell Depletion with Rituximab in Graves Disease and Associated Orbitopathy
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) New Organ-Specific Pharmacological Strategies Interfering With Signaling Pathways In Inflammatory Disorders/Autoimmune Disorders
Current Signal Transduction Therapy The Therapeutic use of the Zonulin Inhibitor AT-1001 (Larazotide) for a Variety of Acute and Chronic Inflammatory Diseases
Current Medicinal Chemistry Synthetic and Biological Vesicular Nano-Carriers Designed for Gene Delivery
Current Pharmaceutical Design Dosage Form Developments of Nanosuspension Drug Delivery System for Oral Administration Route
Current Pharmaceutical Design Angiogenesis Inhibitors: Current & Future Directions
Current Pharmaceutical Design Design of Magnetic Nanoparticles-Assisted Drug Delivery System
Current Pharmaceutical Design Radiation Safety During Interventions of Coronary Chronic Total Occlusion
Current Cardiology Reviews Chemical Approaches for Live Cell Bioimaging
Combinatorial Chemistry & High Throughput Screening Peptide Mediated Brain Delivery of Nano- and Submicroparticles: A Synergistic Approach
Current Pharmaceutical Design Sodium Iodate-Induced Mouse Model of Age-Related Macular Degeneration Displayed Altered Expression Patterns of Sumoylation Enzymes E1, E2 and E3
Current Molecular Medicine