Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery

Title: Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery

Volume: 2 Issue: 4

Author(s): Yves Landry and J. P. Gies

Affiliation:

Keywords: heterotrimeric g protein, transmambrane signaling, heptahelical receptor, r g s protein

Abstract: Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their a and bg subunits to effectors including adenylylcyclases, ion channels, phospholipases Cb, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.

Cite this article as:

Landry Yves and Gies P. J., Heterotrimeric G Proteins Control Diverse Pathways of Transmembrane Signaling, a Base for Drug Discovery, Mini-Reviews in Medicinal Chemistry 2002; 2 (4) . https://dx.doi.org/10.2174/1389557023405945