A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO₂ Under Solvent-Free Conditions

Title: A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO₂ Under Solvent-Free Conditions

Volume: 9 Issue: 1

Author(s): Manoj B. Gawande, Deepak M. Nagrik and Damodar M. Ambhore

Affiliation:

Keywords: DHPMs, green synthesis, multicomponent reactions (MCRs), MgO-ZrO2, medicinal chemistry, alkaloids, Biginelli dihydropyrimidinones, Hantzsh type, batzelladine, anticancer drugs

Abstract: An efficient green synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones (DHPMs) using MgO/ZrO2 as heterogeneous basic catalyst from an aldehyde, β-keto ester and urea/thiourea under solvent-free conditions is described. A variety of aldehydes were studied with β-keto ester and urea/thiourea giving good to excellent yield of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones. This protocol has advantage of excellent yield, reusability, inexpensive and short reaction time at room temperature. The synthesized catalyst can be reused up to 5 consecutive cycles without any decrease in the yield.

Cite this article as:

B. Gawande Manoj, M. Nagrik Deepak and M. Ambhore Damodar, A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO₂ Under Solvent-Free Conditions, Letters in Organic Chemistry 2012; 9 (1) . https://dx.doi.org/10.2174/157017812799303980