Prevention of Intracerebral Haemorrhage

Title: Prevention of Intracerebral Haemorrhage

Volume: 8 Issue: 7

Author(s): Patrick Mitchell, Dipayan Mitra, Barbara A. Gregson and A. David Mendelow

Affiliation:

Keywords: ictohaemorrhagic lesion, antithrombotic, embolisation, Arteriovenous malformations, Aneurysms

Abstract: Nontraumatic intracerebral haemorrhages arise from a wide range of causes falling into two broad groups: discreet vascular “ictohaemorrhagic” lesions such as aneurysms, arteriovenous malformations, cavernomas, tumours, and dural fistulae; and more generalised amyloid or hypertension related conditions. It is now possible using family history, associated risk factors and gradient echo MRI to predict cases at high risk of hypertensive or amyloid related haemorrhage. There is considerable potential for prevention of hypertensive haemorrhages by treatment of high risk cases with antihypertensive medication. As yet no effective preventative treatment for amyloid angiopathy related ICH has emerged although a variety of drugs are under investigation. Prevention of haemorrhage from ictohaemorrhagic lesions revolves around removal or obliteration of the lesion. Although there is a wide range of such lesions available treatments come down to three modalities. These are surgical excision, stereotactic radiosurgery and endovascular embolisation.

Cite this article as:

Patrick Mitchell , Dipayan Mitra , Barbara A. Gregson and A. David Mendelow , Prevention of Intracerebral Haemorrhage, Current Drug Targets 2007; 8 (7) . https://dx.doi.org/10.2174/138945007781077328