Abstract
The Sonogashira cross-coupling reaction involves the coupling of terminal alkynes with aryl or vinyl halides in the presence of a Pd and a Cu(I) co-catalyst. We tried to reveal the importance of the applications of the Sonogashira reaction in the synthesis of heterocyclic compounds. The reactions occur under relatively mild conditions and tolerate a wide variety of functional groups.
Keywords: Sonogashira, palladium, Pd-catalyzed, Cu-catalyzed, Cu-free, 2-Formyl/acetyl-N-substituted pyrrolo[2, 3-b]quinoxaline, H-Pyrazolo[5, 1-a]isoquinolines, name reaction.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
48
9