Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient

Title:Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient

Volume: 10 Issue: 1

Author(s): Amol S. Aiwale, Utkarsh A. Patel, Manish J. Barvaliya, Pramod R. Jha and Chandrabhanu Tripathi

Affiliation:

Keywords: Adverse drug reaction, alcohol, convulsions, isoniazid, pyridoxine deficiency, smoking.

Abstract: We report a case of isoniazid induced convulsions in 35 years old male alcoholic and smoker patient receiving intensive phase therapy for pulmonary tuberculosis. A case was confirmed by accidental positive de-challenge and rechallenge as well as ruled out other conditions. Use of isoniazid in alcoholic and smoker patient required a caution for prevention of neurological adverse reactions. Pyridoxine should always be prescribed to such patients for the prevention of such adverse reaction.

Cite this article as:

Aiwale S. Amol, Patel A. Utkarsh, Barvaliya J. Manish, Jha R. Pramod and Tripathi Chandrabhanu, Isoniazid Induced Convulsions at Therapeutic Dose in an Alcoholic and Smoker Patient, Current Drug Safety 2015; 10 (1) . https://dx.doi.org/10.2174/1574886309666140930151343