Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances

Title:Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances

Volume: 22 Issue: 11

Author(s): Reema Savaliya, Poornima Singh and Sanjay Singh

Affiliation:

Keywords: Drug delivery, cancer nanotechnology, nanomaterials, siRNA silencing, cell penetrating peptides.

Abstract: The latest pharmacologic research has resulted number of new molecules with the potential to modernize the prevention or treatment of different complex diseases, including cancer. The therapeutics generally include moieties such as proteins, drugs and genes, etc. Current activities in the pharmacological field include the development of novel drug-delivery systems to overcome pharmacokinetic glitches such as limited bioavailability, unwanted distribution, drug resistant, and stability, etc. Therefore, to address these issues various biotechnological and pharmacological techniques has been introduced. However, effective drug delivery with improved efficacy remains challenging. This review is focused towards different strategies such as physical and biological methods for efficacious delivery at desired tissues and even sub-cellular targeting. Emphasis is also given about nanotechnology based drug or gene delivery strategies and co-delivery of drug-drug; gene-gene or combinations of drug-gene, etc. are the current cuttingedge methods, which are under clinical or pre-clinical stage of research. Uses of biodegradable materials, such as liposomes and polymeric particles are another class of drug delivery vehicles, which have shown tremendous success, are also discussed. Towards the end, future directions of pharmacological drug delivery methods have also been summarized.

Cite this article as:

Savaliya Reema, Singh Poornima and Singh Sanjay, Pharmacological Drug Delivery Strategies for Improved Therapeutic Effects: Recent Advances, Current Pharmaceutical Design 2016; 22 (11) . https://dx.doi.org/10.2174/1381612822666151210123546