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Applied Drug Research, Clinical Trials and Regulatory Affairs

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ISSN (Print): 2667-3371
ISSN (Online): 2667-338X

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Research Article

Efficacy of Topical Formulations in Healing of Caesarean Scars Using Non-Invasive Devices: A Controlled Trial

Author(s): Alia Abdullah, Rawya Al Kredly and Mohamed Baguneid*

Volume 8, Issue 2, 2021

Published on: 28 December, 2020

Article ID: e301221189506 Pages: 8

DOI: 10.2174/2213476X07999201228111027

Price: $65

Abstract

Background: Despite the availability of many topical formulations for scar treatment, an objective evaluation of their effectiveness is lacking.

Objective: To assess the physiological, structural, and mechanical parameters of scar healing by a scar ointment (MEBO-Scar).

Methods: 45 patients from the Department of Obstetrics at Al Ain Hospital, UAE, with recently acquired Pfannenstiel scars were recruited into this prospective, open-label, controlled study. Scar ointment was applied to a lateral third of the scar; positive control (silicone gel based topical) to the other lateral third; the middle third was left untreated (negative control). The scars were evaluated at 4 time points up to 12 weeks using non-invasive devices and a scar questionnaire.

Results: In comparison with silicone gel, there was a significant reduction in trans epithelial water loss at weeks 2, 4, 8, and 12 (p<0.001) and scar area at weeks 4, 8 and 12 (p<0.001) with scar ointment. The skin elasticity at week 4 was significantly increased by scar ointment (p=0.007). By week 12, gross colour mismatch of the scar was described by 9% patients with scar ointment (24% with silicone gel, 42% with no treatment; p<0.001). There was a significant improvement in scar texture with scar ointment by week 12 (p<0.001).

Conclusion: Scar ointment has beneficial effects on objective and subjective patient-reported parameters of Pfannenstiel scars.

Keywords: Scar treatment, MEBO-Scar ointment, patient reported outcomes, dermalab, manchester scar scale, wound healing

Graphical Abstract

[1]
Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. Nature 2008; 453(7193): 314-21.
[http://dx.doi.org/10.1038/nature07039] [PMID: 18480812]
[2]
Eming SA, Krieg T, Davidson JM. Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007; 127(3): 514-25.
[http://dx.doi.org/10.1038/sj.jid.5700701] [PMID: 17299434]
[3]
Sidgwick GP, McGeorge D, Bayat A. A comprehensive evidence-based review on the role of topicals and dressings in the management of skin scarring. Arch Dermatol Res 2015; 307(6): 461-77.
[http://dx.doi.org/10.1007/s00403-015-1572-0] [PMID: 26044054]
[4]
Son D, Harijan A. Overview of surgical scar prevention and management. J Korean Med Sci 2014; 29(6): 751-7.
[http://dx.doi.org/10.3346/jkms.2014.29.6.751] [PMID: 24932073]
[5]
Bayat A, McGrouther DA, Ferguson MW. Skin scarring. BMJ 2003; 326(7380): 88-92.
[http://dx.doi.org/10.1136/bmj.326.7380.88] [PMID: 12521975]
[6]
Bleasdale B, Finnegan S, Murray K, Kelly S, Percival SL. The use of silicone adhesives for scar reduction. Adv Wound Care (New Rochelle) 2015; 4(7): 422-30.
[http://dx.doi.org/10.1089/wound.2015.0625] [PMID: 26155385]
[7]
Ngaage M, Agius M. The psychology of scars: A mini-review. Psychiatr Danub 2018; 30 (Suppl. 7): 633-8.
[PMID: 30439862]
[8]
Brown BC, McKenna SP, Siddhi K, McGrouther DA, Bayat A. The hidden cost of skin scars: quality of life after skin scarring. J Plast Reconstr Aesthet Surg 2008; 61(9): 1049-58.
[http://dx.doi.org/10.1016/j.bjps.2008.03.020] [PMID: 18617450]
[9]
Gold MH, McGuire M, Mustoe TA, et al. International Advisory Panel on Scar Management. Updated international clinical recommendations on scar management: part 2--algorithms for scar prevention and treatment. Dermatol Surg 2014; 40(8): 825-31.
[PMID: 25068544]
[10]
Majeed MUA. The use of MEBO Scar ointment in the treatment and prevention of post-operative wound scars. Int J Pharma Res Health Sci 2016; 4: 1171-8.
[http://dx.doi.org/10.21276/ijprhs.2016.03.05]
[11]
Basson R, Baguneid M, Foden P, Al Kredly R, Bayat A. Functional testing of a skin topical formulation in vivo: objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with sequential punch biopsies. Adv Wound Care (New Rochelle) 2019; 8(5): 208-19.
[http://dx.doi.org/10.1089/wound.2018.0864] [PMID: 31737415]
[12]
Zuo Z, Su P, Li H, et al. Effects of MEBO scar lotion on microstructure of hypertrophic scars. J Binzhou Medical University 2002; 25: 6-7.
[13]
Liu W, Liu S, Bin S, et al. The efficacy obervation of MEBO scar lotion in treating hypertrophic scar by means of b-type ultrasound instrument for scar measurement (attached 470 cases of report). Chinese J Burns Wounds Surface Ulcers 2010; 22: 213-5.
[14]
Li C, Liang X, Guang C. Clinical observation in treating skin pruritus of healed burns with MEBO scar lotion. Chinese J Burns Wounds Surface Ulcers 2007; 19: 316-8.
[15]
Fu Z, Wang X. Clinical study of MEBO SCAReducer in the prevention and treatment of scarring. Chinese J Burns Wounds Surface Ulcers 2011; 23: 93-6.
[16]
Fabbrocini G, Marasca C, Ammad S, et al. Assessment of the combined efficacy of needling and the use of silicone gel in the treatment of c-section and other surgical hypertrophic scars and keloids. Adv Skin Wound Care 2016; 29(9): 408-11.
[http://dx.doi.org/10.1097/01.ASW.0000490028.37994.14] [PMID: 27538108]
[17]
Mustoe TA. Evolution of silicone therapy and mechanism of action in scar management. Aesthetic Plast Surg 2008; 32(1): 82-92.
[http://dx.doi.org/10.1007/s00266-007-9030-9] [PMID: 17968615]
[18]
Fearmonti R, Bond J, Erdmann D, Levinson H. A review of scar scales and scar measuring devices. Eplasty 2010; 10: e43.
[PMID: 20596233]
[19]
Hua W, Fan LM, Dai R, et al. Comparison of two series of non-invasive instruments used for the skin physiological properties measurements: the DermaLab® from Cortex Technology vs. the series of detectors from Courage & Khazaka. Skin Res Technol 2017; 23(1): 70-8.
[http://dx.doi.org/10.1111/srt.12303] [PMID: 27637867]
[20]
Anthonissen M, Daly D, Fieuws S, et al. Measurement of elasticity and transepidermal water loss rate of burn scars with the Dermalab(®). Burns 2013; 39(3): 420-8.
[http://dx.doi.org/10.1016/j.burns.2012.07.026] [PMID: 23000371]
[21]
Akdeniz M, Gabriel S, Lichterfeld-Kottner A, Blume-Peytavi U, Kottner J. Transepidermal water loss in healthy adults: a systematic review and meta-analysis update. Br J Dermatol 2018; 179(5): 1049-55.
[http://dx.doi.org/10.1111/bjd.17025] [PMID: 30022486]
[22]
Mustoe TA, Gurjala A. The role of the epidermis and the mechanism of action of occlusive dressings in scarring. Wound Repair Regen 2011; 19 (Suppl. 1): s16-21.
[http://dx.doi.org/10.1111/j.1524-475X.2011.00709.x] [PMID: 21793961]
[23]
Cohen BE, Geronemus RG, McDaniel DH, Brauer JA. The Role of Elastic Fibers in Scar Formation and Treatment. Dermatol Surg 2017; 43 (Suppl. 1): S19-24.
[http://dx.doi.org/10.1097/DSS.0000000000000840] [PMID: 27399940]
[24]
Almine JF, Wise SG, Weiss AS. Elastin signaling in wound repair. Birth Defects Res C Embryo Today 2012; 96(3): 248-57.
[http://dx.doi.org/10.1002/bdrc.21016] [PMID: 23109320]

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