Presence of Distinct Virtual Backbone Torsion angles in Dipeptide Conformers

Title: Presence of Distinct Virtual Backbone Torsion angles in Dipeptide Conformers

Volume: 9 Issue: 2

Author(s): S. Gupta, B.M. Grail and J.W. Payne

Affiliation:

Keywords: dipeptide conformus, torsion angle, zwitterionic dipeptide, specific, virsual torsion, molecular recognition template

Abstract: Zwitterionic dipeptides have recently been shown to exist in water mainly as nine conformational forms with specific combinations of backbone ψ, ω and φ torsions, which allows conformer-specific molecular recognition of peptide ligands by proteins. Here, we show that pairs of virtual backbone torsions can also define these nine conformational forms, and that comparing these virtual torsions in dipeptides with those of backbone-modified pseudopeptides offers an improved procedure for evaluating peptidomimetics for therapeutic applications.

Cite this article as:

Gupta S., Grail B.M. and Payne J.W., Presence of Distinct Virtual Backbone Torsion angles in Dipeptide Conformers, Protein & Peptide Letters 2002; 9 (2) . https://dx.doi.org/10.2174/0929866023408904