Abstract
A new and facile one-pot synthesis of the biologically important spiro[quinazoline/pyrimidine]ones scaffold was synthesized simply by the reaction of isatin, 1,3-dione and urea or thiourea. The scope of the reaction was successfully extended by employing two other reactive ketones (acenaphthylene-1,2-dione and ninhydrin) instead of isatin. A series of new spiro cyclic derivatives via multi-component reaction was obtained by using guanidine and employing different 1,3 - dicarbonyl compounds.
Keywords: Acenaphthylene-1, 2-dione, 1, 3-Dicarbonyls, dihydropyrimidinone, isatin, multi-component reaction, ninhydrin, spiroheterocycles.
Related Books
2-Deoxy-D-Glucose: Chemistry and Biology
Chiral Ionic Liquids: Applications in Chemistry and Technology
Basics of Organic Chemistry: A Textbook for Undergraduate Students
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
28