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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Structure / Function Relationships within the Rna Recognition Motif Family applied to the Hermes Gene Product

Author(s): Laurent Thion and Monique Erard

Volume 9, Issue 2, 2002

Page: [127 - 132] Pages: 6

DOI: 10.2174/0929866023408841

Price: $65

Abstract

The RNA Recognition Motif (RRM) family of RNA-binding domains comprises distinct structural subclasses which can be equated to various types of cognate RNAs in relation to biological functions. By identifying structural templates within the appropriate RRM subclass, we have homology-modelled the threedimensional structure of the hermes gene-encoded RRM. Our findings lead us to propose potential RNA targets for the corresponding protein and to predict possible functions in RNA metabolism during heart development.

Keywords: rrm, rna, binding domain, cognate rna, gene, encoded rrm, rna targets


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