“Dipeptoids”: From the Chemical Structure of the Endogenous Peptide to the Design of Peptidomimetics

Title: “Dipeptoids”: From the Chemical Structure of the Endogenous Peptide to the Design of Peptidomimetics

Volume: 4 Issue: 6

Author(s): Mercedes Martin-Martinez, Rosario Patino-Molina, M. Teresa Garcia-Lopez and Rosario Gonzalez-Muniz

Affiliation:

Keywords: dipeptoids, cholecystokinin, peptidomimetics, rational design

Abstract: The present review details the rational multi-step process followed for the discovery of a family of non-peptide CCK receptor ligands (“dipeptoids”), starting from the structure of the endogenous peptide, CCK8. Emphasis will be made on the N- and C-terminal modifications, on the singular effects of the stereochemical changes and the incorporation of conformational constraints into the structure of “dipeptoids”, and on the modifications directed to improve the pharmacological profile of these compounds to afford valuable clinical candidates.

Cite this article as:

Martin-Martinez Mercedes, Patino-Molina Rosario, Garcia-Lopez Teresa M. and Gonzalez-Muniz Rosario, “Dipeptoids”: From the Chemical Structure of the Endogenous Peptide to the Design of Peptidomimetics, Mini-Reviews in Medicinal Chemistry 2004; 4 (6) . https://dx.doi.org/10.2174/1389557043403701