Abstract
Treatment of thia analogues of protoberberine alkaloids, 13-carboxy-13,13a-dihydro-6H,8H-isoquinolino [2,3-c][1,3]benzothiazin-8-ones, with thionyl chloride, followed by ethanol, unexpectedly provided 5,11-dioxoindeno [1,2-c]isoquinoline derivatives containing a novel ring system. Elucidation of their structures is presented in this paper. The antiproliferative effects of thiaprotoberberines and indenoisoquinolines were determined by MTT assay against a set of human adherent cancer cell lines (Hela, MCF7 and A431).
Keywords: Benzothiazine, indenoisoquinoline, MTT assay, thia-protoberberine, thionyl, chloride, alkaloids, ethanol, topoisomerases, chromatin
Letters in Organic Chemistry
Title: Unexpected Formation of Indenoisoquinoline Derivatives from Thia Analogues of Protoberberine Alkaloids
Volume: 8 Issue: 7
Author(s): Lajos Fodor, Peter Csomos, Judit Molnar, Istvan Zupko, Antal Csampai and Pal Sohar
Affiliation:
Keywords: Benzothiazine, indenoisoquinoline, MTT assay, thia-protoberberine, thionyl, chloride, alkaloids, ethanol, topoisomerases, chromatin
Abstract: Treatment of thia analogues of protoberberine alkaloids, 13-carboxy-13,13a-dihydro-6H,8H-isoquinolino [2,3-c][1,3]benzothiazin-8-ones, with thionyl chloride, followed by ethanol, unexpectedly provided 5,11-dioxoindeno [1,2-c]isoquinoline derivatives containing a novel ring system. Elucidation of their structures is presented in this paper. The antiproliferative effects of thiaprotoberberines and indenoisoquinolines were determined by MTT assay against a set of human adherent cancer cell lines (Hela, MCF7 and A431).
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Cite this article as:
Fodor Lajos, Csomos Peter, Molnar Judit, Zupko Istvan, Csampai Antal and Sohar Pal, Unexpected Formation of Indenoisoquinoline Derivatives from Thia Analogues of Protoberberine Alkaloids, Letters in Organic Chemistry 2011; 8 (7) . https://dx.doi.org/10.2174/157017811796504981
DOI https://dx.doi.org/10.2174/157017811796504981 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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