Abstract
The last decade has witnessed a growing interest in natural and synthetic polysulfanes and their potential uses in Medicine and Agriculture. Whilst the chemistry and biochemistry of these organic sulfur compounds is slowly emerging and biological applications are being put into practice, their inorganic equivalents, the hydrogen polysulfides, have attracted little attention so far. Recently, studies conducted in the field of hydrogen sulfide (H2S) signaling have revealed a potential role of such simple sulfur molecules in the redox control of cysteine proteins and associated, extensive cellular signaling. It is therefore worthwhile to consider more closely the chemistry of inorganic polysulfides, their possible formation and occurrence in Biology and likely interactions with biologically relevant functional groups and molecules. Here, a specific focus seems to be on thiol and disulfide groups in proteins and enzymes of the cellular thiolstat.
Keywords: Cellular thiolstat, cysteine modification, hydrogen sulfide, polysulfide, redox modulation, signaling.
Graphical Abstract
Current Organic Chemistry
Title:Polysulfides in Biology: From Intricate Chemistry to an Astonishing Yet Hidden Biological Activity
Volume: 20 Issue: 2
Author(s): Ethiene C. Estevam, Lisa Faulstich, Sharoon Griffin, Torsten Burkholz and Claus Jacob
Affiliation:
Keywords: Cellular thiolstat, cysteine modification, hydrogen sulfide, polysulfide, redox modulation, signaling.
Abstract: The last decade has witnessed a growing interest in natural and synthetic polysulfanes and their potential uses in Medicine and Agriculture. Whilst the chemistry and biochemistry of these organic sulfur compounds is slowly emerging and biological applications are being put into practice, their inorganic equivalents, the hydrogen polysulfides, have attracted little attention so far. Recently, studies conducted in the field of hydrogen sulfide (H2S) signaling have revealed a potential role of such simple sulfur molecules in the redox control of cysteine proteins and associated, extensive cellular signaling. It is therefore worthwhile to consider more closely the chemistry of inorganic polysulfides, their possible formation and occurrence in Biology and likely interactions with biologically relevant functional groups and molecules. Here, a specific focus seems to be on thiol and disulfide groups in proteins and enzymes of the cellular thiolstat.
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Cite this article as:
C. Estevam Ethiene, Faulstich Lisa, Griffin Sharoon, Burkholz Torsten and Jacob Claus, Polysulfides in Biology: From Intricate Chemistry to an Astonishing Yet Hidden Biological Activity, Current Organic Chemistry 2016; 20 (2) . https://dx.doi.org/10.2174/1385272819666150724233028
DOI https://dx.doi.org/10.2174/1385272819666150724233028 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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