Abstract
The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-κB pathway whose activation is dependent on the proteasome activity.
Keywords: Proteasome inhibitors, natural products, medicinal compounds, cancer, prevention, treatment
Current Drug Discovery Technologies
Title: Targeting Tumor Proteasome with Traditional Chinese Medicine
Volume: 7 Issue: 1
Author(s): Huanjie Yang, Jinbao Liu and Q. Ping Dou
Affiliation:
Keywords: Proteasome inhibitors, natural products, medicinal compounds, cancer, prevention, treatment
Abstract: The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-κB pathway whose activation is dependent on the proteasome activity.
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Cite this article as:
Yang Huanjie, Liu Jinbao and Ping Dou Q., Targeting Tumor Proteasome with Traditional Chinese Medicine, Current Drug Discovery Technologies 2010; 7 (1) . https://dx.doi.org/10.2174/157016310791162785
DOI https://dx.doi.org/10.2174/157016310791162785 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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