Inhibitors of the TGF-β Superfamily and their Clinical Applications

Title: Inhibitors of the TGF-β Superfamily and their Clinical Applications

Volume: 6 Issue: 11

Author(s): K. Tsuchida, Y. Sunada, S. Noji, T. Murakami, A. Uezumi and M. Nakatani

Affiliation:

Keywords: TGF-β, activin, BMP, cancer, fibrosis, follistatin, myostatin, muscular dystrophy

Abstract: The transforming growth factor-β (TGF-β) superfamily includes TGF-β s, activin, myostatin and bone morphogenetic proteins. Misregulation of the activity of TGF-β family members is involved in pathogenesis of cancer, muscular dystrophy, obesity and bone and tooth remodeling. Natural inhibitors for the TGF-β superfamily regulate fine-tuning of activity of TGF-β family in vivo. In addition to natural inhibitors for the TGF-βfamily, soluble forms of receptors for the TGF-β family, blocking monoclonal antibodies and small chemical TGF-β inhibitors have been developed. In this review, we summarize recent advances in our understanding of inhibitors for the TGF-β superfamily and their medical applications.

Cite this article as:

Tsuchida K., Sunada Y., Noji S., Murakami T., Uezumi A. and Nakatani M., Inhibitors of the TGF-β Superfamily and their Clinical Applications, Mini-Reviews in Medicinal Chemistry 2006; 6 (11) . https://dx.doi.org/10.2174/138955706778742759