The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment

Title: The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment

Volume: 15 Issue: 12

Author(s): Hannelore Denys, Geert Braems, Kathleen Lambein, Patrick Pauwels, An Hendrix, Astrid De Boeck, Veronique Mathieu, Marc Bracke and Olivier De Wever

Affiliation:

Abstract: Emerging evidence points towards a key role of the extracellular matrix (ECM) during tumor progression and therapy resistance. Paradoxically, in todays routine of cancer management the ECM is not taken into account. It is the aim of the present review to broaden our understanding of the mechanisms of therapy resistance, taking the ECM as a presumptive central regulator. The stromal ecosystem drives the accumulation of ECM at the invasion front. Therefore, we address the question whether the detection of ECM signatures in histopathology and biofluids may help predicting therapy resistance and determining the prognosis of cancer. Since the ECM is an attractive target for tumor therapy, current therapeutic strategies in preclinical or clinical development will be discussed.

Cite this article as:

Denys Hannelore, Braems Geert, Lambein Kathleen, Pauwels Patrick, Hendrix An, De Boeck Astrid, Mathieu Veronique, Bracke Marc and De Wever Olivier, The Extracellular Matrix Regulates Cancer Progression and Therapy Response: Implications for Prognosis and Treatment, Current Pharmaceutical Design 2009; 15 (12) . https://dx.doi.org/10.2174/138161209787846711