Abstract
In order to overcome the significant side effects and the acquired resistance of platinum-based anticancer drugs, great efforts have been devoted to designing new platinum compounds or non-platinum transition metal anticancer complexes with improved pharmacological properties and a broader range of antitumor activity. Among them, the new complexes based on natural alkaloid and their derivatives provide a novel approach to potential (pro-)drugs. This review was mainly focused on the recent progresses of alkaloid-metal based anticancer agents, including metal complexes of natural or synthetic alkaloids, liriodenine, β-carboline, and quinolinoline as anticancer agents, their in vitro anticancer activities and primary action mechanism. Additionally, the future development of hybrid alkaloid and its derivatives metal complexes as anticancer drugs was discussed, which might hold a promise for overcoming multidrug resistance (MDR).
Keywords: Alkaloid, liriodenine, β-carboline alkaloid, quinolinoline, anticancer agents, metal complexes.
Current Topics in Medicinal Chemistry
Title:Alkaloid-Metal Based Anticancer Agents
Volume: 13 Issue: 17
Author(s): Zhen-Feng Chen, Yan-Cheng Liu, Ke-Bin Huang and Hong Liang
Affiliation:
Keywords: Alkaloid, liriodenine, β-carboline alkaloid, quinolinoline, anticancer agents, metal complexes.
Abstract: In order to overcome the significant side effects and the acquired resistance of platinum-based anticancer drugs, great efforts have been devoted to designing new platinum compounds or non-platinum transition metal anticancer complexes with improved pharmacological properties and a broader range of antitumor activity. Among them, the new complexes based on natural alkaloid and their derivatives provide a novel approach to potential (pro-)drugs. This review was mainly focused on the recent progresses of alkaloid-metal based anticancer agents, including metal complexes of natural or synthetic alkaloids, liriodenine, β-carboline, and quinolinoline as anticancer agents, their in vitro anticancer activities and primary action mechanism. Additionally, the future development of hybrid alkaloid and its derivatives metal complexes as anticancer drugs was discussed, which might hold a promise for overcoming multidrug resistance (MDR).
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Cite this article as:
Chen Zhen-Feng, Liu Yan-Cheng, Huang Ke-Bin and Liang Hong, Alkaloid-Metal Based Anticancer Agents, Current Topics in Medicinal Chemistry 2013; 13 (17) . https://dx.doi.org/10.2174/15680266113139990146
DOI https://dx.doi.org/10.2174/15680266113139990146 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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