Abstract
Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.
Keywords: MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP
Anti-Cancer Agents in Medicinal Chemistry
Title: Does More MnSOD Mean More Hydrogen Peroxide?
Volume: 11 Issue: 2
Author(s): Lee Ann MacMillan-Crow and John P. Crow
Affiliation:
Keywords: MnSOD, superoxide, hydrogen peroxide, nitric oxide, peroxynitrite, oxidant-sensitive fluorophore, metalloproteinases, H2O2, ONOO, nanomolar concentrations, DCDHF, proliferation, ischemia/reperfusion injury, horseradish peroxidase or HRP
Abstract: Superoxide dismutases (SODs) are a family of important antioxidant enzymes that catalyze the conversion of superoxide to hydrogen peroxide and oxygen. Hydrogen peroxide is then detoxified by a host of antioxidant enzymes. A common misconception is that the increased MnSOD levels will result in increased hydrogen peroxide levels. Herein we offer some potential reasons for this confusion, as well as some potential resolutions. Data are offered that demonstrate the ability of MnSOD, in the presence of nitric oxide, to utilize hydrogen peroxide to produce superoxide and the more toxic oxidant, peroxynitrite.
Export Options
About this article
Cite this article as:
Ann MacMillan-Crow Lee and P. Crow John, Does More MnSOD Mean More Hydrogen Peroxide?, Anti-Cancer Agents in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/187152011795255939
DOI https://dx.doi.org/10.2174/187152011795255939 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Small Heat Shock Proteins and the Endoplasmic Reticulum: Potential Attractive Therapeutic Targets?
Current Molecular Medicine Expression and Function of MicroRNAs in Heart Disease
Current Drug Targets An Increasing Incidence of Treatment Resistance in Hypertension?
Current Drug Therapy Synthetic Cannabinoids as Drugs of Abuse
Current Drug Abuse Reviews Drugs as Possible Triggers of Takotsubo Cardiomyopathy: A Comprehensive Literature Search - Update 2015
Current Clinical Pharmacology Is the Vascular System a Main Target for Thyroid Hormones? From Molecular and Biochemical Findings to Clinical Perspectives
Current Vascular Pharmacology A Comprehensive Review of Pharmacokinetics and Pharmacodynamics in Animals: Exploration of Interaction with Antibiotics of Shuang-Huang- Lian Preparations
Current Topics in Medicinal Chemistry Decoding the Transcriptional Response to Ischemic Stroke in Obese and Non-obese Mice Brain
Current Neurovascular Research Conventional and Non-Conventional Targets of Natural Products in the Management of Diabetes Mellitus and Associated Complications
Current Medicinal Chemistry Adeno-associated Viral Vectors for Correction of Inborn Errors of Metabolism: Progressing Towards Clinical Application
Current Pharmaceutical Design ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications
Current Drug Targets A Review of Maternal and Fetal Growth Factors in Diabetic Pregnancy
Current Diabetes Reviews Molecular Genetics of Left Ventricular Dysfunction
Current Molecular Medicine Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders
Current Medicinal Chemistry Effect of Aging on Metabolic Pathways in Endothelial Progenitor Cells
Current Pharmaceutical Design Calcium Ions in Inherited Cardiomyopathies
Medicinal Chemistry Inotropic and Vasoactive Drugs in Pediatric ICU
Current Drug Targets Anti Diabetic Evaluation of Methanolic Extract of <i>Psoralea corylifolia</i> L. & <i>Psoralea esculenta</i> L. Seeds in Streptozotocin Induced Diabetic Rats and Histopathological Changes in Diabetic Rats Pancreas: A Comparative Study
The Natural Products Journal Evaluation and Management of Atrial Fibrillation
Cardiovascular & Hematological Disorders-Drug Targets Asymmetric Dimethylarginine (ADMA): A Promising Biomarker for Cardiovascular Disease?
Current Topics in Medicinal Chemistry