The Use of Anthracyclines for Therapy of CNS Tumors

Title:The Use of Anthracyclines for Therapy of CNS Tumors

Volume: 15 Issue: 6

Author(s): Martina da Ros, Anna Lisa Iorio, Maurizio Lucchesi, Alessia Stival, Maurizio de Martino and Iacopo Sardi

Affiliation:

Keywords: Anthracyclines, blood brain barrier, brain diseases, drug delivery systems, drug efflux proteins, multidrug resistance.

Abstract: Despite being long lived, anthracyclines remain the “evergreen” drugs in clinical practice of oncology, showing a potent effect in inhibiting cell growth in many types of tumors, including brain neoplasms. Unfortunately, they suffer from a poor penetration into the brain when intravenously administered due to multidrug resistance mechanism, which hampers their delivery across the blood brain barrier.

In this paper, we summarize the current literature on the role of anthracyclines in cancer therapy and highlight recent efforts on 1) development of tumor cell resistance to anthracyclines and 2) the new approaches to brain drug delivery across the blood brain barrier.

Cite this article as:

Ros da Martina, Iorio Lisa Anna, Lucchesi Maurizio, Stival Alessia, Martino de Maurizio and Sardi Iacopo, The Use of Anthracyclines for Therapy of CNS Tumors, Anti-Cancer Agents in Medicinal Chemistry 2015; 15 (6) . https://dx.doi.org/10.2174/1871520615666150407155319