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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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General Review Article

L-carnitine: Searching for New Therapeutic Strategy for Sepsis Management

Author(s): Adeleh Sahebnasagh, Razieh Avan, Mahila Monajati, Javad Hashemi, Solomon Habtemariam, Sina Negintaji and Fatemeh Saghafi*

Volume 29, Issue 18, 2022

Published on: 14 January, 2022

Page: [3300 - 3323] Pages: 24

DOI: 10.2174/0929867328666211117092345

Price: $65

Abstract

In this review, we discussed the biological targets of carnitine, its effects on immune function, and how L-carnitine supplementation may help critically ill patients. L-carnitine is a potent antioxidant. L-carnitine depletion has been observed in prolonged intensive care unit (ICU) stays, while L-carnitine supplementation has beneficial effects in health promotion and regulation of immunity. It is essential for the uptake of fatty acids into mitochondria. By inhibiting the ubiquitin-proteasome system, down-regulating the apelin receptor in cardiac tissue, and reducing β-oxidation of fatty acid, carnitine may decrease vasopressor requirement in septic shock and improve clinical outcomes of this group of patients. We also reviewed animal and clinical studies that have been recruited for evaluating the beneficial effects of L-carnitine in the management of sepsis/ septic shock. Additional clinical data are required to evaluate the optimal daily dose and duration of L-carnitine supplementation.

Keywords: L-carnitine, sepsis, septic shock, critically ill, intensive care, antioxidant.

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