Abstract
One of the most surprising aspects of neural development is that cells do not remain in their birthplace but actively migrate along a variety of routes to their final destinations. This review traces past, present, and future techniques used to analyze progenitor cell migration in the brain, and also discusses their relevant strengths and weaknesses. The large majority of information regarding cell migration is from studies where migratory cells have been labeled, but in which the actual movements are not observed, ie., from static experiments. More recently, dynamic imaging of cell migration in living slices and, even in vivo, has provided a glimpse of how complex these phenomena truly are. A variety of new techniques, such as 2-photon videomicroscopy, are emerging that will continue to add to our body of knowledge concerning the migration of cells in the central nervous system.
Keywords: Subventricular zone, migration, multiphoton, nucleokinesis, development, imaging, videomicroscopy
Current Pharmaceutical Biotechnology
Title: Techniques and Strategies to Analyze Neural Progenitor Cell Migration
Volume: 8 Issue: 3
Author(s): Isabelle Comte, Phuong B. Tran and Francis G. Szele
Affiliation:
Keywords: Subventricular zone, migration, multiphoton, nucleokinesis, development, imaging, videomicroscopy
Abstract: One of the most surprising aspects of neural development is that cells do not remain in their birthplace but actively migrate along a variety of routes to their final destinations. This review traces past, present, and future techniques used to analyze progenitor cell migration in the brain, and also discusses their relevant strengths and weaknesses. The large majority of information regarding cell migration is from studies where migratory cells have been labeled, but in which the actual movements are not observed, ie., from static experiments. More recently, dynamic imaging of cell migration in living slices and, even in vivo, has provided a glimpse of how complex these phenomena truly are. A variety of new techniques, such as 2-photon videomicroscopy, are emerging that will continue to add to our body of knowledge concerning the migration of cells in the central nervous system.
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Cite this article as:
Isabelle Comte , Phuong B. Tran and Francis G. Szele , Techniques and Strategies to Analyze Neural Progenitor Cell Migration, Current Pharmaceutical Biotechnology 2007; 8 (3) . https://dx.doi.org/10.2174/138920107780906513
DOI https://dx.doi.org/10.2174/138920107780906513 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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