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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Use of Intravenous Aminobisphosphonates for the Treatment of Pagets Disease of Bone

Author(s): Luigi Gennari, Daniela Merlotti, Giuseppe Mossetti, Domenico Rendina, Vincenzo De Paola, Giuseppe Martini and Ranuccio Nuti

Volume 9, Issue 9, 2009

Page: [1052 - 1063] Pages: 12

DOI: 10.2174/138955709788922683

Price: $65

Abstract

Pagets disease of bone is a focal skeletal disorder characterized by the formation of structurally abnormal bone, deformity and other complications leading to significant disability and bone pain. Recently, the availability of newer, more potent nitrogen-containing bisphosphonates has improved treatment outcomes, allowing a more effective and convenient management of this disorder.

Keywords: Paget's disease of bone, bone turnover, bisphosphonates, zoledronic acid, pamidronate, neridronate


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