Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS

Title:Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS

Volume: 22 Issue: 14

Author(s): Hongchuan Liu, Zhixia Zhao, Yingkai Wang, Lihong Liu, Yuanhua Yang and Zhuoling An*

Affiliation:

• Department of Pharmacy, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

Keywords: HPLC-MS/MS, rivaroxaban, plasma concentration, anti-Xa activity, therapeutic drug monitoring, deep-vein thrombosis.

Abstract: Objective: The aim of the study was to investigate a high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method for the determination of rivaroxaban and evaluate the correlation between plasma concentration and anti-Xa activity in patients using oral rivaroxaban.

Methods: In this study, the plasma concentration of rivaroxaban and anti-Xa factor activities was determined in 125 patients, and the relationship between the two variables was analysed by SPSS 21.0 software.

Results: The results showed that the plasma concentrations of oral rivaroxaban patients were significantly correlated with the activity of the anti-Xa factor (Spearman’s r = 0.990, P < 0.05).

Conclusion: The plasma concentrations of rivaroxaban are a potentially useful monitoring indicator to assess the patient’s bleeding risk if testing for plasma anti-Xa activity is not available.

Cite this article as:

Liu Hongchuan , Zhao Zhixia , Wang Yingkai , Liu Lihong, Yang Yuanhua and An Zhuoling*, Study on the Relationship between Rivaroxaban and Factor Xa Activity in Blood Based on HPLC-MS/MS, Current Drug Metabolism 2021; 22 (14) . https://dx.doi.org/10.2174/1389200222666211126093627