Abstract
COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side effects of COX-2 inhibitors. Nonetheless, they remain a valuable option for postoperative pain management. The pharmacology of these agents and available studies are reviewed.
Keywords: Celecoxib, parecoxib, postoperative pain
Current Topics in Medicinal Chemistry
Title: COX-2 Inhibitors Celecoxib and Parecoxib: Valuable Options for Postoperative Pain Management
Volume: 7 Issue: 3
Author(s): Noor M. Gajraj
Affiliation:
Keywords: Celecoxib, parecoxib, postoperative pain
Abstract: COX-2 inhibitors are equally as efficacious as the non-selective NSAIDs for the treatment of postoperative pain, but have the advantages of a better gastrointestinal side-effect profile as well as a lack of antiplatelet effects. There have been recent concerns regarding the cardiovascular side effects of COX-2 inhibitors. Nonetheless, they remain a valuable option for postoperative pain management. The pharmacology of these agents and available studies are reviewed.
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Gajraj M. Noor, COX-2 Inhibitors Celecoxib and Parecoxib: Valuable Options for Postoperative Pain Management, Current Topics in Medicinal Chemistry 2007; 7 (3) . https://dx.doi.org/10.2174/156802607779941323
DOI https://dx.doi.org/10.2174/156802607779941323 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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