Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients

Title:Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients

Volume: 22 Issue: 14

Author(s): Ling Wang, Mingguang Chen, Hong Ye, Xiaolan Lin, Yixuan Li, Junshan Ruan*, Fenghui Lin*Yuxing Lin

Affiliation:

• Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China
• Department of Pharmacy, Fujian Provincial Hospital, Fuzhou, China

• Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China
• Cardiac Intensive Care Unit, Fujian Provincial Hospital, Fuzhou, China

Keywords: Teicoplanin, Critically ill, Elderly, Blood concentration, pharmacokinetics, pharmacodynamics.

Abstract: Background: Significant changes in the pathophysiology of older critically ill patients may affect the pharmacokinetics and pharmacodynamics of teicoplanin. This study aimed to determine the optimal teicoplanin blood level in this patient population.

Methods: 128 older critically ill and 86 older non-critically ill patients were involved and analyzed.

Results: The target thresholds of teicoplanin blood concentrations in older critically ill patients and non-critically ill patients should be 31.4mg/L and 15.3mg/L, respectively. The dose of teicoplanin in older critically ill patients should be greater than 800 mg to achieve the target blood level.

Conclusion: An individualized dosing approach of teicoplanin based on therapeutic drug monitoring is necessary for older critically ill patients.

Cite this article as:

Wang Ling , Chen Mingguang, Ye Hong , Lin Xiaolan, Li Yixuan , Ruan Junshan *, Lin Fenghui*, Lin Yuxing, Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients, Current Drug Metabolism 2021; 22 (14) . https://dx.doi.org/10.2174/1389200222666211122124420