The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer

Title:The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer

Volume: 20 Issue: 9

Author(s): Xi Zeng, Hao-Ying Wang, Su-Yang Bai, Ke Pu, Yu-Ping Wang and Yong-Ning Zhou*

Affiliation:

• Department of Gastroenterology, The first Hospital of Lanzhou University, Lanzhou,China

Keywords: microRNAs, chemotherapy, multidrug resistance, gastric cancer, mechanisms, MDR.

Abstract: Multidrug resistance (MDR) is one of the most significant reasons for the chemotherapeutics failure in gastric cancer. Although accumulating investigations and researches have been made to elucidate the mechanisms of multidrug resistance, the detail is far from completely understood. The importance of microRNAs in cancer chemotherapeutic resistance has been demonstrated recently, which provides a new strategy to overcome multidrug resistance. The different mechanisms are related to the phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which MDR is acquired. In turn, the aim of this review was to summarize recent publications of microRNAs in regulating MDR in gastric cancer, thereby potentially developing as targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms including the ATP-binding cassette (ABC) transporter family, autophagy induction, cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic regulation, and exosomes in gastric cancer will be helpful for us to win the battle against it.

Cite this article as:

Zeng Xi , Wang Hao-Ying , Bai Su-Yang , Pu Ke , Wang Yu-Ping and Zhou Yong-Ning *, The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer, Current Molecular Medicine 2020; 20 (9) . https://dx.doi.org/10.2174/1566524020666200226124336