摘要
多药耐药性(MDR)是胃癌化疗失败的最重要原因之一。尽管已经进行了累加的调查研究以阐明多药耐药性的机制,但其细节还远未完全弄清。最近已经证明了microRNA在癌症化疗耐药性中的重要性,这提供了克服多药耐药性的新策略。不同的机制与MDR本身的现象以及miRNA在获得MDR的这些多种机制中的作用有关。反过来,本综述的目的是总结最近在胃癌中调控MDR的microRNA中的作用,从而有可能发展为靶向疗法。进一步阐明microRNA在MDR机制中的作用,包括ATP结合盒(ABC)转运蛋白家族,自噬诱导,癌症干细胞调节,缺氧诱导,DNA损伤和修复,表观遗传调节以及胃癌的外泌体将对我们有帮助赢得与之抗衡。
关键词: microRNA,化学疗法,多药耐药性,胃癌,机制,MDR。
Current Molecular Medicine
Title:The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer
Volume: 20 Issue: 9
关键词: microRNA,化学疗法,多药耐药性,胃癌,机制,MDR。
摘要: Multidrug resistance (MDR) is one of the most significant reasons for the chemotherapeutics failure in gastric cancer. Although accumulating investigations and researches have been made to elucidate the mechanisms of multidrug resistance, the detail is far from completely understood. The importance of microRNAs in cancer chemotherapeutic resistance has been demonstrated recently, which provides a new strategy to overcome multidrug resistance. The different mechanisms are related to the phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which MDR is acquired. In turn, the aim of this review was to summarize recent publications of microRNAs in regulating MDR in gastric cancer, thereby potentially developing as targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms including the ATP-binding cassette (ABC) transporter family, autophagy induction, cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic regulation, and exosomes in gastric cancer will be helpful for us to win the battle against it.
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Cite this article as:
The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer, Current Molecular Medicine 2020; 20 (9) . https://dx.doi.org/10.2174/1566524020666200226124336
DOI https://dx.doi.org/10.2174/1566524020666200226124336 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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