Abstract
We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
Keywords: E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer
Mini-Reviews in Medicinal Chemistry
Title: E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment
Volume: 8 Issue: 5
Author(s): E. W. Howard, K. D. Camm, Y. C. Wong and X. H. Wang
Affiliation:
Keywords: E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer
Abstract: We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.
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Cite this article as:
Howard W. E., Camm D. K., Wong C. Y. and Wang H. X., E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment, Mini-Reviews in Medicinal Chemistry 2008; 8 (5) . https://dx.doi.org/10.2174/138955708784223521
DOI https://dx.doi.org/10.2174/138955708784223521 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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