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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

E-Cadherin Upregulation as a Therapeutic Goal in Cancer Treatment

Author(s): E. W. Howard, K. D. Camm, Y. C. Wong and X. H. Wang

Volume 8, Issue 5, 2008

Page: [496 - 518] Pages: 23

DOI: 10.2174/138955708784223521

Price: $65

Abstract

We review the role of E-cadherin in cancer progression, and its therapeutic restoration as a strategy to suppress metastasis. We subsequently discuss E-cadherin upregulating drugs, proposing a schema for restoring E-cadherin by targeting its epigenetic and transcriptional regulators. These pathways will likely provide significant future treatment breakthroughs against cancer metastasis.

Keywords: E-cadherin, cell adhesion, epithelial-mesenchymal transition, epigenetics, transcriptional repressors, chemotherapy, metastasis, cancer


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