Abstract
Multidrug resistance (MDR) is one of the most significant reasons for the chemotherapeutics failure in gastric cancer. Although accumulating investigations and researches have been made to elucidate the mechanisms of multidrug resistance, the detail is far from completely understood. The importance of microRNAs in cancer chemotherapeutic resistance has been demonstrated recently, which provides a new strategy to overcome multidrug resistance. The different mechanisms are related to the phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which MDR is acquired. In turn, the aim of this review was to summarize recent publications of microRNAs in regulating MDR in gastric cancer, thereby potentially developing as targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms including the ATP-binding cassette (ABC) transporter family, autophagy induction, cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic regulation, and exosomes in gastric cancer will be helpful for us to win the battle against it.
Keywords: microRNAs, chemotherapy, multidrug resistance, gastric cancer, mechanisms, MDR.
Current Molecular Medicine
Title:The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer
Volume: 20 Issue: 9
Author(s): Xi Zeng, Hao-Ying Wang, Su-Yang Bai, Ke Pu, Yu-Ping Wang and Yong-Ning Zhou*
Affiliation:
- Department of Gastroenterology, The first Hospital of Lanzhou University, Lanzhou,China
Keywords: microRNAs, chemotherapy, multidrug resistance, gastric cancer, mechanisms, MDR.
Abstract: Multidrug resistance (MDR) is one of the most significant reasons for the chemotherapeutics failure in gastric cancer. Although accumulating investigations and researches have been made to elucidate the mechanisms of multidrug resistance, the detail is far from completely understood. The importance of microRNAs in cancer chemotherapeutic resistance has been demonstrated recently, which provides a new strategy to overcome multidrug resistance. The different mechanisms are related to the phenomena of MDR itself and the roles of miRNAs in these multi-mechanisms by which MDR is acquired. In turn, the aim of this review was to summarize recent publications of microRNAs in regulating MDR in gastric cancer, thereby potentially developing as targeted therapies. Further unraveling the roles of microRNAs in MDR mechanisms including the ATP-binding cassette (ABC) transporter family, autophagy induction, cancer stem cell regulation, hypoxia induction, DNA damage and repair, epigenetic regulation, and exosomes in gastric cancer will be helpful for us to win the battle against it.
Export Options
About this article
Cite this article as:
Zeng Xi , Wang Hao-Ying , Bai Su-Yang , Pu Ke , Wang Yu-Ping and Zhou Yong-Ning *, The Roles of microRNAs in Multidrug-Resistance Mechanisms in Gastric Cancer, Current Molecular Medicine 2020; 20 (9) . https://dx.doi.org/10.2174/1566524020666200226124336
DOI https://dx.doi.org/10.2174/1566524020666200226124336 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cellular and Physiological Effects of Soy Flavonoids
Mini-Reviews in Medicinal Chemistry Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine
Current Pharmaceutical Design Novel Short AMP: Design and Activity Study
Protein & Peptide Letters Addressing the Challenge: Current and Future Directions in Ovarian Cancer Therapy
Current Gene Therapy Glioblastoma Multiforme Formation and EMT: Role of FoxM1 Transcription Factor
Current Pharmaceutical Design FOXO1: A Potential Target for Human Diseases
Current Drug Targets Patent Selections
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) The Quest for a Tumor Suppressor Gene Phenotype
Current Molecular Medicine Autophagy and Ubiquitination as Two Major Players in Colorectal Cancer: A Review on Recent Patents
Recent Patents on Anti-Cancer Drug Discovery Cell Dormancy and Tumor Refractory
Anti-Cancer Agents in Medicinal Chemistry The Immunomodulation and Anti-Inflammatory Effects of Garlic Organosulfur Compounds in Cancer Chemoprevention
Anti-Cancer Agents in Medicinal Chemistry Exercise for the Overweight and Obese
Current Pharmaceutical Design Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration
Current Drug Metabolism Design and Synthesis of 4(1H)-quinolone Derivatives as Autophagy Inducing Agents by Targeting ATG5 Protein
Letters in Drug Design & Discovery Phytochemical Investigation and Antimutagenic Potential of Ethanolic Extracts of Emblica officinalis, Terminalia chebula and Terminalia bellirica
The Natural Products Journal Antitumor Effect of Butanoylated Heparin with Low Anticoagulant Activity on Lung Cancer Growth in Mice and Rats
Current Cancer Drug Targets The Role of LEF/TCF Factors in Neoplastic Transformation
Current Molecular Medicine Peptide Aptamers: Development and Applications
Current Topics in Medicinal Chemistry Recent Progress in the Pharmacology of Imidazo[1,2-a]pyridines
Mini-Reviews in Medicinal Chemistry Gas1 is a Pleiotropic Regulator of Cellular Functions: from Embryonic Development to Molecular Actions in Cancer Gene Therapy
Mini-Reviews in Medicinal Chemistry