New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer

Title:New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer

Volume: 22 Issue: 16

Author(s): Christophe Erneux, Somadri Ghosh, Ana Raquel Ramos and William`s Elong Edimo

Affiliation:

Keywords: Signal Transduction, cancer, phosphoinositide, inositol polyphosphate 5-phosphatase, breast cancer, glioblastoma, migration, invasion.

Abstract: Inositol polyphosphate 5-phosphatases act on inositol phosphates and phosphoinositides as substrates. They are 10 different isoenzymes and several splice variants in the human genome that are involved in a series of human pathologies such as the Lowe syndrome, the Joubert and MORM syndromes, breast cancer, glioblastoma, gastric cancer and several other type of cancers. Inositol 5-phosphatases can be amplified in human cancer cells, whereas the 3- and 4- phosphatase tumor suppressor PTEN and INPP4B, repectively are often repressed or deleted. The inositol 5-phosphatases are critically involved in a complex network of higly regulated phosphoinositides, affecting the lipid content of PI(3, 4, 5)P₃, PI(4, 5)P₂ and PI(3, 4)P₂. This has an impact on the normal behavior of many intracellular target proteins e.g. protein kinase B (PKB/Akt) or actin binding proteins and final biological responses. The production of PI(3, 4P)₂ by dephosphorylation of the substrate PI(3, 4, 5)P₃ is particularly important as it produces a new signal messenger in the control of cell migration, invasion and endocytosis. New inhibitors/activators of inositol 5- phosphatases have recently been identified for the possible control of their activity in several human pathologies such as inflamation and cancer.

Cite this article as:

Erneux Christophe, Ghosh Somadri, Ramos Raquel Ana and Edimo Elong William`s, New Functions of the Inositol Polyphosphate 5-Phosphatases in Cancer, Current Pharmaceutical Design 2016; 22 (16) . https://dx.doi.org/10.2174/1381612822666160226132512