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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Case Report

ORO-Dental Manifestations in West Syndrome

Author(s): Fedora della Vella*, Maria Contaldo , Renato Fucile, ">Francesco Panza, Vittorio Dibello, Zamira Kalemaj, Rossella Ninivaggi, Massimo Petruzzi and Rosario Serpico

Volume 19, Issue 31, 2019

Page: [2824 - 2828] Pages: 5

DOI: 10.2174/1568026619666191114122732

Price: $65

Abstract

Background: West Syndrome is a rare epileptic encephalopathy involving infantile spasms, altered electroencephalographic pattern with hypsarrhythmia, and psychomotor development delay. It arises in paediatric patients, generally within the first year of life, in symptomatic or idiopathic form depending on the presence of hereditary features or not.

Case Report: In this report it is described the case of a West syndrome patient affected by multiple caries, gingival enlargement, dental eruption abnormalities, high-arched palate and MIH, treated at the dental clinic of University of Bari “Aldo Moro”.

Discussion: West patients present with multiple oral abnormalities, including altered eruption timing, teeth agenesis, teeth shape and position abnormalities, plaque and calculus accumulation, malocclusions and bad oral habits (mouth breathing, nails biting).

Conclusion: West Syndrome patients’ oral hygiene is generally bad due to their motor difficulty and to their low compliance towards dentists, which entails general anaesthesia to perform dental treatment. West Syndrome pharmacological treatment is usually based on antiepileptic drugs and/or ACTH. These medications are well known for their ability to induce gingival enlargement, increasing the possibility of plaque accumulation and gingivitis development.

Keywords: West Syndrome, Special needs, Epilepsy, ORO-dental, Epileptic, MRI.

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Graphical Abstract

[1]
Lux, A.L.; Osborne, J.P. A proposal for case definitions and outcome measures in studies of infantile spasms and west syndrome: consensus statement of the West Delphi group. Epilepsia, 2004, 45(11), 1416-1428.
[http://dx.doi.org/10.1111/j.0013-9580.2004.02404.x] [PMID: 15509243]
[2]
Souza, V.M.A.; Pereira, A.M.; Palmini, A. West Syndrome, autism and epilepsy: resolution of the epilepsy and recover of autism after surgery. J. Epilepsy Clin. Neurophysiol., 2008, 14(1), 33-37.
[http://dx.doi.org/10.1590/S1676-26492008000100008]
[3]
Jansen, K.; Vandeput, S.; Van Huffel, S.; Lagae, L. Cardiac autonomic dysfunction in west syndrome. Epilepsy Res., 2012, 102(3), 167-172.
[http://dx.doi.org/10.1016/j.eplepsyres.2012.05.010] [PMID: 22727657]
[4]
West, W.J. On a peculiar form of infantile convulsions. Lancet, 1841, 911(35), 742-745.
[http://dx.doi.org/10.1016/S0140-6736(00)40184-4]
[5]
Pies, N.J.; Beardsmore, C.W. West & West syndrome--a historical sketch about the eponymous doctor, his work and his family. Brain Dev., 2003, 25(2), 84-101.
[http://dx.doi.org/10.1016/S0387-7604(02)00161-4] [PMID: 12581804]
[6]
Hrachovy, R.A.; Frost, J.D. Severe encephalopathic epilepsy in infants: infantile spasms (west syndrome).Undefined. Pediatric Epilepsy, 3rd ed; Pellock, J.M.; Bourgeois, B.F.D.; Dodson, W.E., Eds.; Demos Medical Publishing: New York 2008, 16.
[7]
Sankar, R.; Koh, S.; Wu, J.; Menkes, J.H. Paroxysmal disorders. Child neurology; Menkes, J.H.; Sarnat, H.B.; Maria, B.L.; eds. 7th ed. Lippincott Williams & Wilkins: Philadelphia 2006, 857-942.
[8]
Albuquerque, M.; Muszkat, M.; Vergani, M.I.C.; Campos, C.J.R. West syndrome: report of 25 cases. Rev. Paul. Pediatr., 1990, 8(29), 76-78.
[9]
Dulac, O. What is West syndrome? Brain Dev., 2001, 23(7), 447-452.
[http://dx.doi.org/10.1016/S0387-7604(01)00268-6] [PMID: 11701238]
[10]
Brna, P.M.; Gordon, K.E.; Dooley, J.M.; Wood, E.P. The epidemiology of infantile spasms. Can. J. Neurol. Sci., 2001, 28(4), 309-312.
[http://dx.doi.org/10.1017/S0317167100001517] [PMID: 11766774]
[11]
Nordli, D.R., Jr; Pellock, J.M.; Sankar, R.; Wheless, J.W. Pellock’s pediatric epilepsy: diagnosis and therapy; Springer Publishing Company: New York, 2016.
[12]
Zeka, N.; Gërguri, A.; Bejiqi, R.; Retkoceri, R.; Vuciterna, A. Compare of the west syndrome with other syndromes in the epileptic encephalopathy. Open Access Maced. J. Med. Sci., 2017, 5(7), 925-928.
[http://dx.doi.org/10.3889/oamjms.2017.192] [PMID: 29362620]
[13]
Abu Saleh, T.; Stephen, L. Lennox gastaut syndrome, review of the literature and a case report. Head Face Med., 2008, 4, 9.
[http://dx.doi.org/10.1186/1746-160X-4-9] [PMID: 18541034]
[14]
Aicardi, J. Disease of Nervous system in childhood, 3rd ed; Mac Keith, 2009, pp. 593-597.
[15]
Nash, K.; Sullivan, J. Myoclonic seizures and infantile spasms, 2012.
[http://dx.doi.org/10.1016/B978-1-4377-0435-8.00056-1]
[16]
Garza, M.D. Paroxysmal Disorders. Fenichel’s Clinical Pediatric Neurology, 7th ed; Elsevier Saunders: Philadelphia, 2013, pp. 1-46.
[http://dx.doi.org/10.1016/B978-1-4557-2376-8.00001-3]
[17]
Tungare, S.; Paranjpe, A.G. Drug Induced Gingival Overgrowth (DIGO); StatPearls Publishing: Treasure Island, 2019.
[18]
Mauz, P.S.; Mörike, K.; Kaiserling, E.; Brosch, S. Valproic acid-associated sialadenosis of the parotid and submandibular glands: diagnostic and therapeutic aspects. Acta Otolaryngol., 2005, 125(4), 386-391.
[http://dx.doi.org/10.1080/00016480410024460] [PMID: 15823809]
[19]
Lee, H.; Lee, J.Y.; Ha, D.H.; Jeong, J.H.; Park, J.B. Effects of valproic acid on morphology, proliferation, and differentiation of mesenchymal stem cells derived from human gingival tissue. Implant Dent., 2018, 27(1), 33-42.
[http://dx.doi.org/10.1097/ID.0000000000000711] [PMID: 29329119]
[20]
ASA Physical Status Classification System.https://www.asahq.org/standards-and-guidelines/asa-physical-status-classification-system (Accessed on 12th May 2019).
[21]
Ministero della Salute.www.salute.gov (Accessed on 12th May 2019).
[22]
William, V.; Messer, L.B.; Burrow, M.F. Molar incisor hypomineralization: review and recommendations for clinical management. Pediatr. Dent., 2006, 28(3), 224-232.
[PMID: 16805354]
[23]
Marshall, R.I.; Bartold, P.M. Medication induced gingival overgrowth. Oral Dis., 1998, 4(2), 130-151.
[http://dx.doi.org/10.1111/j.1601-0825.1998.tb00269.x] [PMID: 9680902]
[24]
Bussell, R.M.; Deery, C. Case report: Blue chromogenic dental staining in child with West syndrome. Eur. Arch. Paediatr. Dent., 2010, 11(6), 298-300.
[http://dx.doi.org/10.1007/BF03262767] [PMID: 21108922]
[25]
Regis, R.R.; Rocha, C.T.; Torres, C.P.; Queiroz, I.F.; de Queiroz, A.M. Oral findings and dental treatment in a child with West syndrome. Spec. Care Dentist., 2009, 29(6), 259-263.
[http://dx.doi.org/10.1111/j.1754-4505.2009.00106.x] [PMID: 19886939]
[26]
Khatri, A.; Kalra, N.; Tyagi, R.; Baweja, M.; Khandelwal, D. Dental findings in patients with West syndrome: a report of two cases. J. Indian Soc. Pedod. Prev. Dent., 2014, 32(2), 168-171.
[http://dx.doi.org/10.4103/0970-4388.130988] [PMID: 24739920]
[27]
Dantas-Neta, N.B.; Carvalho e Souza, C.H.; Mendes Alencar, S.M.; Prado Júnior, R.R.; Mendes, R.F. Dental findings in children with West syndrome. Spec. Care Dentist., 2014, 34(6), 291-294.
[http://dx.doi.org/10.1111/scd.12068] [PMID: 25353658]
[28]
Tan, H.; Gürbüz, T.; Dağsuyu, I.M. Gingival enlargement in children treated with antiepileptics. J. Child Neurol., 2004, 19(12), 958-963.
[http://dx.doi.org/10.1177/08830738040190120901] [PMID: 15704870]
[29]
Lafzi, A.; Farahani, R.M.; Shoja, M.A. Phenobarbital-induced gingival hyperplasia. J. Contemp. Dent. Pract., 2007, 8(6), 50-56.
[http://dx.doi.org/10.5005/jcdp-8-6-50] [PMID: 17846671]
[30]
Anderson, H.H.; Rapley, J.W.; Williams, D.R. Gingival overgrowth with valproic acid: a case report. ASDC J. Dent. Child., 1997, 64(4), 294-297.
[PMID: 9328685]
[31]
Lin, K.; Guilhoto, L.M.F.F.; Yacubian, E.M.T. Drug-induced gingival enlargement – Part II. Antiepileptic drugs: not only phenytoin is involved. J. Epilepsy Clin. Neurophysiol., 2007, 13(2), 83-88.
[http://dx.doi.org/10.1590/S1676-26492007000200009]

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