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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Clinical Trial

Decreased Plasma Level of Lipoprotein Lipase Predicted Verbal Disfluency in Chinese Type 2 Diabetes Mellitus Patients with Early Cognitive Deficits

Author(s): Ke An , Peng Guo, Haoqiang Zhang, Wenwen Zhu , Wuyou Cao, Jijing Shi and Shaohua Wang*

Volume 18, Issue 8, 2021

Published on: 21 September, 2021

Page: [656 - 666] Pages: 11

DOI: 10.2174/1567205018666210922105850

Price: $65

Abstract

Background: Lipoprotein Lipase (LPL) is the rate-limiting enzyme catalyzing the hydrolysis of triglycerides and contributes to the amyloid-β formation, which shows promise as a pathological factor of cognitive decline in Type 2 Diabetes Mellitus (T2DM). This study aimed to investigate the pathogenetic roles of LPL and rs328 polymorphism in Mild Cognitive Impairment (MCI) in patients with T2DM.

Methods: Chinese patients with T2DM were recruited and divided into two groups based on the Montreal Cognitive Assessment score. Demographic data were collected, LPL was measured and neuropsychological test results were examined.

Results: Seventy-nine patients with diabetes and MCI had significantly decreased plasma LPL levels (p = 0.007) when compared with health-cognition controls (n = 91). Correlation analysis revealed that LPL was positively correlated with clock drawing test (r = 0.158, p = 0.043) and logical memory test (r = 0.162, p = 0.037), while lipoprotein a (r = -0.214, p = 0.006) was inversely associated with LPL. Logistic regression analysis further demonstrated that LPL concentration was an independent factor for diabetic MCI (p = 0.036). No significant differences were observed in the distributions of rs328 variants between patients with MCI and the controls. Moreover, no remarkable association was found among plasma LPL levels, cognitive performances, and lipid levels between the genotypic subgroups. The trail making test A was increased in the GC group when compared with the CC genotype in the control group.

Conclusion: Decreased plasma level of LPL could probably predict early cognitive deficits, especially verbal disfluency.

Keywords: Lipoprotein lipase, mild cognitive impairment, executive function, memory function, type 2 diabetes mellitus, rs328.

« Previous
[1]
Ritchie K, Touchon J. Mild cognitive impairment: conceptual basis and current nosological status. Lancet 2000; 355(9199): 225-8.
[http://dx.doi.org/10.1016/S0140-6736(99)06155-3] [PMID: 10675135]
[2]
Kersten S. Physiological regulation of lipoprotein lipase. Biochim Biophys Acta 2014; 1841(7): 919-33.
[http://dx.doi.org/10.1016/j.bbalip.2014.03.013] [PMID: 24721265]
[3]
Goldberg IJ, Merkel M. Lipoprotein lipase: physiology, biochemistry, and molecular biology. Front Biosci 2001; 6: D388-405.
[PMID: 11229871]
[4]
He P-P, Jiang T, OuYang X-P, Liang Y-Q, Zou J-Q, Wang Y. Lipoprotein lipase: Biosynthesis, regulatory factors, and its role in atherosclerosis and other diseases. Clinica chimica acta; international journal of clinical chemistry 2018; 480: 126-37.
[5]
Bessesen DH, Richards CL, Etienne J, Goers JW, Eckel RH. Spinal cord of the rat contains more lipoprotein lipase than other brain regions. J Lipid Res 1993; 34(2): 229-38.
[http://dx.doi.org/10.1016/S0022-2275(20)40750-3] [PMID: 8429258]
[6]
Huey PU, Marcell T, Owens GC, Etienne J, Eckel RH. Lipoprotein lipase is expressed in cultured Schwann cells and functions in lipid synthesis and utilization. J Lipid Res 1998; 39(11): 2135-42.
[http://dx.doi.org/10.1016/S0022-2275(20)32468-8] [PMID: 9799799]
[7]
Paradis E, Clavel S, Julien P, et al. Lipoprotein lipase and endothelial lipase expression in mouse brain: regional distribution and selective induction following kainic acid-induced lesion and focal cerebral ischemia. Neurobiol Dis 2004; 15(2): 312-25.
[http://dx.doi.org/10.1016/j.nbd.2003.09.017] [PMID: 15006701]
[8]
Ding YL, Wang YH, Huang W, et al. Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia. Exp Biol Med (Maywood) 2010; 235(1): 40-6.
[http://dx.doi.org/10.1258/ebm.2009.009100] [PMID: 20404017]
[9]
Wang H, Eckel RH. Lipoprotein lipase: from gene to obesity. Am J Physiol Endocrinol Metab 2009; 297(2): E271-88.
[http://dx.doi.org/10.1152/ajpendo.90920.2008] [PMID: 19318514]
[10]
Hu Y, Ren Y, Luo RZ, et al. Novel mutations of the lipoprotein lipase gene associated with hypertriglyceridemia in members of type 2 diabetic pedigrees. J Lipid Res 2007; 48(8): 1681-8.
[http://dx.doi.org/10.1194/jlr.M600382-JLR200] [PMID: 17476032]
[11]
Xie C, Wang ZC, Liu XF, Yang MS. The common biological basis for common complex diseases: evidence from lipoprotein lipase gene. Eur J Hum Gene Ejhg 2010; 18(1): 3-7.
[http://dx.doi.org/10.1038/ejhg.2009.134] [PMID: 19639021]
[12]
Nishitsuji K, Hosono T, Uchimura K, Michikawa M. Lipoprotein lipase is a novel amyloid beta (Abeta)-binding protein that promotes glycosaminoglycan-dependent cellular uptake of Abeta in astrocytes. J Biol Chem 2011; 286(8): 6393-401.
[http://dx.doi.org/10.1074/jbc.M110.172106] [PMID: 21177248]
[13]
Gong H, Dong W, Rostad SW, et al. Lipoprotein lipase (LPL) is associated with neurite pathology and its levels are markedly reduced in the dentate gyrus of Alzheimer’s disease brains. J Histochem Cytochem 2013; 61(12): 857-68.
[http://dx.doi.org/10.1369/0022155413505601] [PMID: 24004859]
[14]
Baum L, Chen L, Masliah E, Chan YS, Ng HK, Pang CP. Lipoprotein lipase mutations and Alzheimer’s disease. Am J Med Genet 1999; 88(2): 136-9.
[http://dx.doi.org/10.1002/(SICI)1096-8628(19990416)88:2<136::AID-AJMG8>3.0.CO;2-D] [PMID: 10206232]
[15]
Nunes AF, Sousa MM. Transthyretin knockout mouse nerves have increased lipoprotein lipase and sphingolipid content following crush. Neurosci Lett 2008; 446(2-3): 83-7.
[http://dx.doi.org/10.1016/j.neulet.2008.09.054] [PMID: 18834928]
[16]
Sparkes RS, Zollman S, Klisak I, et al. Human genes involved in lipolysis of plasma lipoproteins: mapping of loci for lipoprotein lipase to 8p22 and hepatic lipase to 15q21. Genomics 1987; 1(2): 138-44.
[http://dx.doi.org/10.1016/0888-7543(87)90005-X] [PMID: 3692485]
[17]
Murthy V, Julien P, Gagne C. Molecular pathobiology of the human lipoprotein lipase gene. Pharmacol Ther 1996; 70(2): 101-35.
[http://dx.doi.org/10.1016/0163-7258(96)00005-8] [PMID: 8843465]
[18]
Hata A, Robertson M, Emi M, Lalouel JM. Direct detection and automated sequencing of individual alleles after electrophoretic strand separation: identification of a common nonsense mutation in exon 9 of the human lipoprotein lipase gene. Nucleic Acids Res 1990; 18(18): 5407-11.
[http://dx.doi.org/10.1093/nar/18.18.5407] [PMID: 2216713]
[19]
Rip J, Nierman MC, Ross CJ, et al. Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation. Arterioscler Thromb Vasc Biol 2006; 26(6): 1236-45.
[http://dx.doi.org/10.1161/01.ATV.0000219283.10832.43] [PMID: 16574898]
[20]
Xin X, Srinivasan SR, Chen W, Boerwinkle E, Berenson GS. Interaction effect of Serine447Stop variant of the lipoprotein lipase gene and C-514T variant of the hepatic lipase gene on serum triglyceride levels in young adults: the Bogalusa Heart Study. Metabolism 2003; 52(10): 1337-42.
[http://dx.doi.org/10.1016/S0026-0495(03)00280-4] [PMID: 14564687]
[21]
Sawano M, Watanabe Y, Ohmura H, et al. Potentially protective effects of the Ser447-Ter mutation of the lipoprotein lipase gene against the development of coronary artery disease in Japanese subjects via a beneficial lipid profile. Jpn Circ J 2001; 65(4): 310-4.
[http://dx.doi.org/10.1253/jcj.65.310] [PMID: 11316129]
[22]
Wittrup HH, Tybjaerg-Hansen A, Nordestgaard BG. Lipoprotein lipase mutations, plasma lipids and lipoproteins, and risk of ischemic heart disease. A meta-analysis. Circulation 1999; 99(22): 2901-7.
[http://dx.doi.org/10.1161/01.CIR.99.22.2901] [PMID: 10359734]
[23]
Groenemeijer BE, Hallman MD, Reymer PW, et al. Genetic variant showing a positive interaction with beta-blocking agents with a beneficial influence on lipoprotein lipase activity, HDL cholesterol, and triglyceride levels in coronary artery disease patients. The Ser447-stop substitution in the lipoprotein lipase gene. Circulation 1997; 95(12): 2628-35.
[http://dx.doi.org/10.1161/01.CIR.95.12.2628] [PMID: 9193431]
[24]
Fisher RM, Humphries SE, Talmud PJ. Common variation in the lipoprotein lipase gene: effects on plasma lipids and risk of atherosclerosis. Atherosclerosis 1997; 135(2): 145-59.
[http://dx.doi.org/10.1016/S0021-9150(97)00199-8] [PMID: 9430364]
[25]
Stocks J, Thorn JA, Galton DJ. Lipoprotein lipase genotypes for a common premature termination codon mutation detected by PCR-mediated site-directed mutagenesis and restriction digestion. J Lipid Res 1992; 33(6): 853-7.
[http://dx.doi.org/10.1016/S0022-2275(20)41510-X] [PMID: 1355102]
[26]
Lee J, Tan CS, Chia KS, et al. The lipoprotein lipase S447X polymorphism and plasma lipids: interactions with APOE polymorphisms, smoking, and alcohol consumption. J Lipid Res 2004; 45(6): 1132-9.
[http://dx.doi.org/10.1194/jlr.M400016-JLR200] [PMID: 15060087]
[27]
Baum L, Wiebusch H, Pang CP. Roles for lipoprotein lipase in Alzheimer’s disease: an association study. Microsc Res Tech 2000; 50(4): 291-6.
[http://dx.doi.org/10.1002/1097-0029(20000815)50:4<291::AID-JEMT8>3.0.CO;2-L] [PMID: 10936883]
[28]
Ren L, Ren X. Meta-analyses of four polymorphisms of lipoprotein lipase associated with the risk of Alzheimer’s disease. Neurosci Lett 2016; 619: 73-8.
[http://dx.doi.org/10.1016/j.neulet.2016.03.021] [PMID: 26975783]
[29]
Fidani L, Compton D, Hardy J, et al. No association between the lipoprotein lipase S447X polymorphism and Alzheimer’s disease. Neurosci Lett 2002; 322(3): 192-4.
[http://dx.doi.org/10.1016/S0304-3940(02)00098-8] [PMID: 11897170]
[30]
Xie C, Wang ZC, Liu XF, Yang MS. The common biological basis for common complex diseases: evidence from lipoprotein lipase gene. Eur J Hum Genet 2010; 18(1): 3-7.
[http://dx.doi.org/10.1038/ejhg.2009.134] [PMID: 19639021]
[31]
Martin-Rehrmann MD, Cho HS, Rebeck GW. Lack of association of two lipoprotein lipase polymorphisms with Alzheimer’s disease. Neurosci Lett 2002; 328(2): 109-12.
[http://dx.doi.org/10.1016/S0304-3940(02)00511-6] [PMID: 12133567]
[32]
Jia W, Weng J, Zhu D, et al. Standards of medical care for type 2 diabetes in China 2019. Diabetes Metab Res Rev 2019; 35(6): e3158.
[http://dx.doi.org/10.1002/dmrr.3158] [PMID: 30908791]
[33]
Portet F, Ousset PJ, Visser PJ, et al. Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer’s Disease. J Neurol Neurosurg Psychiatry 2006; 77(6): 714-8.
[http://dx.doi.org/10.1136/jnnp.2005.085332] [PMID: 16549412]
[34]
Zhou BF. Cooperative Meta-Analysis Group of the Working Group on Obesity in China. Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 2002; 15(1): 83-96.
[PMID: 12046553]
[35]
Gil L, Ruiz de Sánchez C, Gil F, Romero SJ, Pretelt Burgos F. Validation of the Montreal Cognitive Assessment (MoCA) in Spanish as a screening tool for mild cognitive impairment and mild dementia in patients over 65 years old in Bogotá, Colombia. Int J Geriatr Psychiatry 2015; 30(6): 655-62.
[http://dx.doi.org/10.1002/gps.4199] [PMID: 25320026]
[36]
Leung JL, Lee GT, Lam YH, Chan RC, Wu JY. The use of the Digit Span Test in screening for cognitive impairment in acute medical inpatients. Int Psychogeriatr 2011; 23(10): 1569-74.
[http://dx.doi.org/10.1017/S1041610211000792] [PMID: 21729426]
[37]
Yoo DH, Lee JS. Clinical usefulness of the clock drawing test applying rasch analysis in predicting of cognitive impairment. J Phys Ther Sci 2016; 28(7): 2140-3.
[http://dx.doi.org/10.1589/jpts.28.2140] [PMID: 27512283]
[38]
Hong X, Zhang ZX, Wu LY, Shi LL, Zhao XH, Wei J. Validity of auditory verbal learning test in diagnosis of Alzheimer’s disease. Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2012; 34(3): 262-6.
[PMID: 22776661]
[39]
Chapman KR, Bing-Canar H, Alosco ML, et al. Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials. Alzheimers Res Ther 2016; 8: 9.
[http://dx.doi.org/10.1186/s13195-016-0176-z] [PMID: 26899835]
[40]
Balota DA, Tse CS, Hutchison KA, Spieler DH, Duchek JM, Morris JC. Predicting conversion to dementia of the Alzheimer’s type in a healthy control sample: the power of errors in Stroop color naming. Psychol Aging 2010; 25(1): 208-18.
[http://dx.doi.org/10.1037/a0017474] [PMID: 20230140]
[41]
Albert MS, Moss MB, Tanzi R, Jones K. Preclinical prediction of AD using neuropsychological tests. J Int Neuropsychol Soc 2001; 7(5): 631-9.
[http://dx.doi.org/10.1017/S1355617701755105] [PMID: 11459114]
[42]
Yu H, Yan H, Wang L, et al. Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study. Lancet Psychiatry 2018; 5(4): 327-38.
[http://dx.doi.org/10.1016/S2215-0366(18)30049-X] [PMID: 29503163]
[43]
Paradis E, Clement S, Julien P, Ven Murthy MR. Lipoprotein lipase affects the survival and differentiation of neural cells exposed to very low density lipoprotein. J Biol Chem 2003; 278(11): 9698-705.
[http://dx.doi.org/10.1074/jbc.M208452200] [PMID: 12501246]
[44]
Zechner R. The tissue-specific expression of lipoprotein lipase: implications for energy and lipoprotein metabolism. Curr Opin Lipidol 1997; 8(2): 77-88.
[http://dx.doi.org/10.1097/00041433-199704000-00005] [PMID: 9183545]
[45]
Blain JF, Paradis E, Gaudreault SB, Champagne D, Richard D, Poirier J. A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain. Neurobiol Dis 2004; 15(3): 510-9.
[http://dx.doi.org/10.1016/j.nbd.2003.12.001] [PMID: 15056458]
[46]
Goti D, Balazs Z, Panzenboeck U, et al. Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model. J Biol Chem 2002; 277(32): 28537-44.
[http://dx.doi.org/10.1074/jbc.M203989200] [PMID: 12032155]
[47]
Traber MG, Olivecrona T, Kayden HJ. Bovine milk lipoprotein lipase transfers tocopherol to human fibroblasts during triglyceride hydrolysis in vitro. J Clin Invest 1985; 75(5): 1729-34.
[http://dx.doi.org/10.1172/JCI111883] [PMID: 3998153]
[48]
Gaubatz JW, Ghanem KI, Guevara J Jr, Nava ML, Patsch W, Morrisett JD. Polymorphic forms of human apolipoprotein[a]: inheritance and relationship of their molecular weights to plasma levels of lipoprotein[a]. J Lipid Res 1990; 31(4): 603-13.
[http://dx.doi.org/10.1016/S0022-2275(20)42828-7] [PMID: 2141054]
[49]
Kostner GM, Avogaro P, Cazzolato G, Marth E, Bittolo-Bon G, Qunici GB. Lipoprotein Lp(a) and the risk for myocardial infarction. Atherosclerosis 1981; 38(1-2): 51-61.
[http://dx.doi.org/10.1016/0021-9150(81)90103-9] [PMID: 7470205]
[50]
Sandholzer C, Boerwinkle E, Saha N, Tong MC, Utermann G. Apolipoprotein(a) phenotypes, Lp(a) concentration and plasma lipid levels in relation to coronary heart disease in a Chinese population: evidence for the role of the apo(a) gene in coronary heart disease. J Clin Invest 1992; 89(3): 1040-6.
[http://dx.doi.org/10.1172/JCI115645] [PMID: 1541665]
[51]
Mooser V, Helbecque N, Miklossy J, Marcovina SM, Nicod P, Amouyel P. Interactions between apolipoprotein E and apolipoprotein(a) in patients with late-onset Alzheimer disease. Ann Intern Med 2000; 132(7): 533-7.
[http://dx.doi.org/10.7326/0003-4819-132-7-200004040-00004] [PMID: 10744589]
[52]
Solfrizzi V, Panza F, D’Introno A, et al. Lipoprotein(a), apolipoprotein E genotype, and risk of Alzheimer’s disease. J Neurol Neurosurg Psychiatry 2002; 72(6): 732-6.
[http://dx.doi.org/10.1136/jnnp.72.6.732] [PMID: 12023414]
[53]
Emanuele E, Peros E, Tomaino C, et al. Relation of apolipoprotein(a) size to alzheimer’s disease and vascular dementia. Dement Geriatr Cogn Disord 2004; 18(2): 189-96.
[http://dx.doi.org/10.1159/000079200] [PMID: 15211075]
[54]
Vyhnálek M, Rubínová E, Marková H, et al. Clock drawing test in screening for Alzheimer’s dementia and mild cognitive impairment in clinical practice. Int J Geriatr Psychiatry 2017; 32(9): 933-9.
[http://dx.doi.org/10.1002/gps.4549] [PMID: 27466038]
[55]
Shulman KI. Clock-drawing: is it the ideal cognitive screening test? Int J Geriatr Psychiatry 2000; 15(6): 548-61.
[http://dx.doi.org/10.1002/1099-1166(200006)15:6<548::AID-GPS242>3.0.CO;2-U] [PMID: 10861923]
[56]
Qiu S, Chang GH, Panagia M, Gopal DM, Au R, Kolachalama VB. Fusion of deep learning models of MRI scans, Mini-Mental State Examination, and logical memory test enhances diagnosis of mild cognitive impairment. Alzheimers Dement (Amst) 2018; 10: 737-49.
[http://dx.doi.org/10.1016/j.dadm.2018.08.013] [PMID: 30480079]
[57]
Gao Y, Xiao Y, Miao R, et al. The characteristic of cognitive function in Type 2 diabetes mellitus. Diabetes Res Clin Pract 2015; 109(2): 299-305.
[http://dx.doi.org/10.1016/j.diabres.2015.05.019] [PMID: 26004430]
[58]
Scheer WD, Boudreau DA, Malcom GT, Middaugh JP. Apolipoprotein E and atherosclerosis in Alaska Natives. Atherosclerosis 1995; 114(2): 197-202.
[http://dx.doi.org/10.1016/0021-9150(94)05483-Y] [PMID: 7605388]
[59]
Rajan KB, Skarupski KA, Rasmussen HE, Evans DA. Gene-environment interaction of body mass index and apolipoprotein E ε4 allele on cognitive decline. Alzheimer Dis Assoc Disord 2014; 28(2): 134-40.
[http://dx.doi.org/10.1097/WAD.0000000000000013] [PMID: 24145695]
[60]
Peacock RE, Hamsten A, Nilsson-Ehle P, Humphries SE. Associations between lipoprotein lipase gene polymorphisms and plasma correlations of lipids, lipoproteins and lipase activities in young myocardial infarction survivors and age-matched healthy individuals from Sweden. Atherosclerosis 1992; 97: 171-85.

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