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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

State of the Art on Carbonic Anhydrase Modulators for Biomedical Purposes

Author(s): Murat Bozdag, Abdulmalik Saleh Alfawaz Altamimi, Daniela Vullo, Claudiu T. Supuran* and Fabrizio Carta*

Volume 26, Issue 15, 2019

Page: [2558 - 2573] Pages: 16

DOI: 10.2174/0929867325666180622120625

Price: $65

Abstract

The current review is intended to highlight recent advances in the search of new and effective modulators of the metalloenzymes Carbonic Anhydrases (CAs, EC 4.2.1.1) expressed in humans (h). CAs reversibly catalyze the CO2 hydration reaction, which is of crucial importance in the regulation of a plethora of fundamental processes at cellular level as well as in complex organisms. The first section of this review will be dedicated to compounds acting as activators of the hCAs (CAAs) and their promising effects on central nervous system affecting pathologies mainly characterized from memory and learning impairments. The second part will focus on the emerging chemical classes acting as hCA inhibitors (CAIs) and their potential use for the treatment of diseases.

Keywords: metalloenzymes, carbonic anhydrases, enzyme activators, enzyme inhibitors, tumors, reumathoid arthritis, glaucoma.

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