Abstract
There is increasing evidence that antimicrobial peptides (AMPs) are differentially regulated in cancers such as oral squamous cell carcinomas (OSCC). Data showing that AMPs influence the growth of tumor cells, exhibit direct cytotoxic activity towards cancer cells, function as a tumor suppressor gene or activate the adaptive immunity suggest that a dysregulation of AMPs may be associated with the development of cancer. There is no question that, with increasing resistance against conventional chemotherapy, novel anticancer agents are needed. It is interesting to speculate that natural AMP or synthetic derivatives can be used to develop novel strategies to fight cancer diseases and may represent a novel family of anticancer agents. However, future research is needed to employ the role of AMPs in cancer and to investigate their role as potential anticancer drugs.
Keywords: Antimicrobial peptide, defensin, cathelicidin, histatin, adrenomedullin, oral cancer, immunotherapy, anticancer effect
Current Pharmaceutical Design
Title: Antimicrobial Peptides in Oral Cancer
Volume: 13 Issue: 30
Author(s): Jens E. Meyer and Jurgen Harder
Affiliation:
Keywords: Antimicrobial peptide, defensin, cathelicidin, histatin, adrenomedullin, oral cancer, immunotherapy, anticancer effect
Abstract: There is increasing evidence that antimicrobial peptides (AMPs) are differentially regulated in cancers such as oral squamous cell carcinomas (OSCC). Data showing that AMPs influence the growth of tumor cells, exhibit direct cytotoxic activity towards cancer cells, function as a tumor suppressor gene or activate the adaptive immunity suggest that a dysregulation of AMPs may be associated with the development of cancer. There is no question that, with increasing resistance against conventional chemotherapy, novel anticancer agents are needed. It is interesting to speculate that natural AMP or synthetic derivatives can be used to develop novel strategies to fight cancer diseases and may represent a novel family of anticancer agents. However, future research is needed to employ the role of AMPs in cancer and to investigate their role as potential anticancer drugs.
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Cite this article as:
Meyer E. Jens and Harder Jurgen, Antimicrobial Peptides in Oral Cancer, Current Pharmaceutical Design 2007; 13 (30) . https://dx.doi.org/10.2174/138161207782110372
DOI https://dx.doi.org/10.2174/138161207782110372 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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