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Review Article

用于生物医学目的的碳酸酐酶调节剂的现有技术

卷 26, 期 15, 2019

页: [2558 - 2573] 页: 16

弟呕挨: 10.2174/0929867325666180622120625

价格: $65

摘要

目前的综述旨在强调最近在寻找新的和有效的人类（h）中表达的金属酶碳酸酐酶（CAs，EC 4.2.1.1）调节剂方面取得的进展。 CA可逆地催化CO 2水合反应，这对于在细胞水平以及复杂生物中调节过多的基本过程是至关重要的。 本综述的第一部分将专门介绍作为hCA（CAAs）激活剂的化合物及其对中枢神经系统的有希望的影响，这些影响主要表现为记忆和学习障碍。 第二部分将重点介绍作为hCA抑制剂（CAIs）的新兴化学类别及其在疾病治疗中的潜在用途。

关键词: 金属酶，碳酸酐酶，酶活化剂，酶抑制剂，肿瘤，类风湿性关节炎，青光眼。

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