Abstract
In this review we will report on recent advanced in polyelectrolyte capsules for targeted drug delivery (eg of growth factor inhibitor) against epatocarcinoma. Degradable polyelectrolyte multilayers capsules (PMCs) are of particular interest for cancer therapy since under physiological conditions they can be enzymatically degraded upon cell interaction. Small bioactive molecules such as TGFBeta inhibitors can be incorporated inside them. Nano-to-microscale delivery systems can enhance efficacy at single cell level for targeted therapy. Layer-by-layer (LbL) self-assembled capsules are novel carriers maximizing drug administration and improving antimetastatic activity of TGF-Beta inhibitors in Hepatocellular Carcinoma (HCC).
Keywords: Polyelectrolytes, capsules, HCC, TGF beta- inhibitor, targeted drug delivery, growth factor inhibitor, epatocarcinoma, polyelectrolyte multilayers capsules (PMCs), cancer therapy, Bevacizumab.
Current Pharmaceutical Design
Title:TGF-Beta Inihibitor-loaded Polyelectrolyte Multilayers Capsules for Sustained Targeting of Hepatocarcinoma Cells
Volume: 18 Issue: 27
Author(s): Viviana Vergaro, Francesca Baldassarre, Flavia De Santis, Giuseppe Ciccarella, Gianluigi Giannelli and Stefano Leporatti
Affiliation:
Keywords: Polyelectrolytes, capsules, HCC, TGF beta- inhibitor, targeted drug delivery, growth factor inhibitor, epatocarcinoma, polyelectrolyte multilayers capsules (PMCs), cancer therapy, Bevacizumab.
Abstract: In this review we will report on recent advanced in polyelectrolyte capsules for targeted drug delivery (eg of growth factor inhibitor) against epatocarcinoma. Degradable polyelectrolyte multilayers capsules (PMCs) are of particular interest for cancer therapy since under physiological conditions they can be enzymatically degraded upon cell interaction. Small bioactive molecules such as TGFBeta inhibitors can be incorporated inside them. Nano-to-microscale delivery systems can enhance efficacy at single cell level for targeted therapy. Layer-by-layer (LbL) self-assembled capsules are novel carriers maximizing drug administration and improving antimetastatic activity of TGF-Beta inhibitors in Hepatocellular Carcinoma (HCC).
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Vergaro Viviana, Baldassarre Francesca, De Santis Flavia, Ciccarella Giuseppe, Giannelli Gianluigi and Leporatti Stefano, TGF-Beta Inihibitor-loaded Polyelectrolyte Multilayers Capsules for Sustained Targeting of Hepatocarcinoma Cells, Current Pharmaceutical Design 2012; 18 (27) . https://dx.doi.org/10.2174/138161212802430404
DOI https://dx.doi.org/10.2174/138161212802430404 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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