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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Review Article

Recent Advances in Methods of Puerarin Biotransformation

Author(s): Guiyou Liu, Zhonghua Liu and Sheng Yuan

Volume 16, Issue 17, 2016

Page: [1392 - 1402] Pages: 11

DOI: 10.2174/1389557516666160505114456

Price: $65

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Abstract

Puerarin is an isoflavonoid extracted from the roots of Pueraria lobata in the Pueraria thomsonii family. Puerarin displays a broad range of pharmacological activities and has been widely used in clinics. However, puerarin’s low solubility and permeability result in poor gastrointestinal absorption and low bioavailability. Simply increasing the dose does not effectively increase bioavailability and might lead to toxicity and side effects. Considerable progress has been achieved in the recent years on puerarin structural biotransformation using microorganisms and free enzymes. Increasingly numerous new puerarin derivatives with high solubility and bioactivity have been developed. This paper reviews recent progress in the biotransformation of puerarin.

Keywords: Biotransformation, Deglycosylation, Glycosylation, Hydroxylation, Puerarin, Research progress.


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