Abstract
Infectious diseases are the most common medical complication after cerebral ischemia, inpairing both the neurological and the general medical outcome. The most frequent infectious complications are bacterial pneumonia and urinary tract infections. There is a growing body of evidence that a secondary immunosuppressive state accounts for the increased risk of infection following stroke. Infections do not only have an important impact on outcome after stroke but also are known risk factors for stroke. Thus, suitable models for investigating the relation between infections and stroke are urgently needed. Elucidating the underlying mechanisms might facilitate the development of new therapeutic strategies and improve patient outcome. Here we present recent insights into the relationship between infections and stroke, based on experimental models of poststroke infection. In addition we give a brief overview of models that explore the impact on stroke of preceding infections.
Keywords: Mouse model, stroke, infection, stroke induced immunodepression, stroke associated infections
Infectious Disorders - Drug Targets
Title: Models of Infection Before and After Stroke: Investigating New Targets
Volume: 10 Issue: 2
Author(s): Odilo Engel and Andreas Meisel
Affiliation:
Keywords: Mouse model, stroke, infection, stroke induced immunodepression, stroke associated infections
Abstract: Infectious diseases are the most common medical complication after cerebral ischemia, inpairing both the neurological and the general medical outcome. The most frequent infectious complications are bacterial pneumonia and urinary tract infections. There is a growing body of evidence that a secondary immunosuppressive state accounts for the increased risk of infection following stroke. Infections do not only have an important impact on outcome after stroke but also are known risk factors for stroke. Thus, suitable models for investigating the relation between infections and stroke are urgently needed. Elucidating the underlying mechanisms might facilitate the development of new therapeutic strategies and improve patient outcome. Here we present recent insights into the relationship between infections and stroke, based on experimental models of poststroke infection. In addition we give a brief overview of models that explore the impact on stroke of preceding infections.
Export Options
About this article
Cite this article as:
Engel Odilo and Meisel Andreas, Models of Infection Before and After Stroke: Investigating New Targets, Infectious Disorders - Drug Targets 2010; 10 (2) . https://dx.doi.org/10.2174/187152610790963546
DOI https://dx.doi.org/10.2174/187152610790963546 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Peptides as Carrier for Tumor Diagnosis and Treatment
Current Medicinal Chemistry - Anti-Cancer Agents Phosphotyrosine Phosphatases in Cancer Diagnostic and Treatment
Recent Patents on DNA & Gene Sequences Determination of Usnic Acid Responsive miRNAs in Breast Cancer Cell Lines
Anti-Cancer Agents in Medicinal Chemistry Navigating the Sea Changes in Patent Law to Successfully Build Value
Technology Transfer and Entrepreneurship (Discontinued) Destroying RNA as a Therapeutic Approach
Current Medicinal Chemistry The Impact of Asymmetric Dimethylarginine (ADAMA), the Endogenous Nitric Oxide (NO) Synthase Inhibitor, to the Pathogenesis of Gastric Mucosal Damage
Current Pharmaceutical Design The Design and Development of Deferiprone (L1) and Other Iron Chelators for Clinical Use: Targeting Methods and Application Prospects
Current Medicinal Chemistry A Comprehensive Review on Recent Developments in the Field of Biological Applications of Potent Pyrazolines Derived from Chalcone Precursors
Letters in Drug Design & Discovery Hyaluronan/Hyaladherins - a Promising Axis for Targeted Drug Delivery in Cancer
Current Drug Delivery Discovery of Multi-target Anticancer Agents Based on HDAC Inhibitor MS-275 and 5-FU
Medicinal Chemistry Genetic Polymorphisms in UDP-Glucuronosyltransferase 1A6 Are Not Associated with NSAIDs-Related Peptic Ulcer Haemorrhage
Drug Metabolism Letters Magnetite Nanostructures with Applications in Cancer Therapy
Current Proteomics Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report
Current Protein & Peptide Science Appraisal of Saxagliptin as Treatment of Type 2 Diabetes
Current Drug Therapy Pharmacometrics of Stilbenes: Seguing Towards the Clinic
Current Clinical Pharmacology 99mTc-HYNIC-D4 Peptide: A New Small Radiolabeled Peptide for Non Small Cell Lung Tumor Targeting
Anti-Cancer Agents in Medicinal Chemistry Efficacy of Yun Zhi (Coriolus versicolor) on Survival in Cancer Patients: Systematic Review and Meta-Analysis
Recent Patents on Inflammation & Allergy Drug Discovery Novel Non-Invasive Protein and Peptide Drug Delivery Approaches
Protein & Peptide Letters Advances in Hydrogels Applied to Degenerative Diseases
Current Pharmaceutical Design HGF-Antagonists: Structure, Activities, and Anti-cancer Approach
Current Signal Transduction Therapy